Pathology Tables for Peer Review
The National Toxicology Program
NTP Experiment-Test: 93027-21 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:55:36
13 WEEK SUBCHRONIC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 25812-30-0
Lock Date: 06/12/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93027-21 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:55:36
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 0 10 100 1000 8000 16,000
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Intestine Large, Rectum (10) (10)
Parasite Metazoan 1 (10%)
Liver (10) (10) (10) (10) (10) (10)
Cytoplasmic Alteration 7 (70%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Infiltration Cellular, Mononuclear Cell 3 (30%)
Inflammation, Chronic Active 2 (20%) 2 (20%) 3 (30%) 2 (20%) 6 (60%) 4 (40%)
Inflammation, Granulomatous 1 (10%)
Necrosis 2 (20%) 2 (20%) 2 (20%) 4 (40%) 4 (40%)
Pancreas (10) (10) (10) (10) (9) (10)
Inflammation, Chronic Active 1 (10%)
Stomach, Forestomach (10) (2) (10)
Mineralization 1 (50%)
Stomach, Glandular (10) (1) (10)
Mineralization 2 (20%) 1 (100%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 1 (10%)
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93027-21 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:55:36
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 0 10 100 1000 8000 16,000
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (9) (10) (10) (10) (10) (9)
Inflammation, Chronic 8 (89%) 9 (90%) 10 (100%) 10 (100%) 9 (90%) 8 (89%)
Testes (10) (10) (9) (10) (9) (10)
Atrophy 1 (10%) 1 (11%)
Mineralization 1 (11%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Hemorrhage 2 (20%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93027-21 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99
Route: DOSED FEED Time: 09:55:36
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS MALE 0 10 100 1000 8000 16,000
PPM PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Nephropathy 8 (80%) 8 (80%) 9 (90%) 8 (80%) 9 (90%) 6 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
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