Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas

This study is currently recruiting participants.

Verified by University of Luebeck, June 2008

Sponsored by:	University of Luebeck
Information provided by:	University of Luebeck
ClinicalTrials.gov Identifier:	NCT00532402

Purpose

This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor. For comparison a discontinuous method is used. Neurophysiologic parameters for determination of depth of anesthesia are compared to the continuous measured propofol concentration in breathing gas.

Study hypothesis: continuous measured propofol concentration in breathing gas correlates to propofol concentration in plasma and depth of anaesthesia.

Condition
General Anesthesia

MedlinePlus related topics: Anesthesia Gas

Drug Information available for: Propofol

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective
Official Title:	Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas - Compared With Propofol Concentration in Plasma (Before and) After Lung Passage and Neurophysiological Parameters

Further study details as provided by University of Luebeck:

Estimated Enrollment:	16
Study Start Date:	September 2007
Estimated Study Completion Date:	September 2008

Eligibility

Ages Eligible for Study:	18 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

Patients having general anesthesia for cardiac and non-cardiac operation

Criteria

Inclusion Criteria:

Patient destined for general anesthesia

Exclusion Criteria:

Heart insufficiency NYHA IV
Allergy to propofol

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00532402

Contacts

Contact: Martin Grossherr, MD

++49-451-5003467

grossher@uni-luebeck.de

Locations

Germany, Schleswig-Holstein
Dept. of Anesthesiology , UK-SH, Campus Luebeck	Recruiting
Luebeck, Schleswig-Holstein, Germany, D-23538
Contact: Martin Grossherr, MD ++49-451-5003467 grossher@uni-luebeck.de
Contact: Hartmut Gehring, MD, PhD ++49-451-5006200 gehring@uni-luebeck.de
Principal Investigator: Martin Grossherr, MD
Dept. of Anesthesiology, UK-SH, Campus Luebeck	Recruiting
Luebeck, Schleswig-Holstein, Germany, D-23538
Dept. of Anesthesiology, UK-SH, Campus Luebeck	Recruiting
Luebeck, Schleswig-Holstein, Germany, D-23538
Contact: Martin Grossherr, MD 0049-451-5003467 grossher@uni-luebeck.de
Sub-Investigator: Susanne Maurmann, MD

Sponsors and Collaborators

University of Luebeck

Investigators

Study Director:

Hartmut Gehring, MD, PhD

Dept of Anesthesiology, UK-SH, Campus Luebeck

More Information

Publications of Results:

Grossherr M, Hengstenberg A, Meier T, Dibbelt L, Gerlach K, Gehring H. Discontinuous monitoring of propofol concentrations in expired alveolar gas and in arterial and venous plasma during artificial ventilation. Anesthesiology. 2006 Apr;104(4):786-90.

Study ID Numbers:	P-A-S-1
Study First Received:	September 18, 2007
Last Updated:	June 2, 2008
ClinicalTrials.gov Identifier:	NCT00532402
Health Authority:	Germany: Ethics Commission

Keywords provided by University of Luebeck:

Monitoring
Breathing Gas
Propofol

Study placed in the following topic categories:

Propofol

Additional relevant MeSH terms:

Anesthetics, Intravenous
Anesthetics, General
Therapeutic Uses
Hypnotics and Sedatives
Physiological Effects of Drugs

Central Nervous System Depressants
Anesthetics
Central Nervous System Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 16, 2009