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Abstract

Title: Analysis of exposure-time-response relationships using a spline weight function.
Author: Hauptmann M, Wellmann J, Lubin JH, Rosenberg PS, Kreienbrock L
Journal: Biometrics 56(4):1105-1108
Year: 2000
Month: December

Abstract: To examine the time-dependent effects of exposure histories on disease, we estimate a weight function within a generalized linear model. The shape of the weight function, which is modeled as a cubic B-spline, gives information about the impact of exposure increments at different times on disease risk. The method is evaluated in a simulation study and is applied to data on smoking histories and lung cancer from a recent case-control study in Germany.