Stem Cells: Scientific Progress and Future Research Directions

This report is a review of the state of the science of stem cell research as of June 17, 2001. Its subject matter addresses stem cells from adult, fetal tissue, and embryonic sources.

The entire report may be downloaded free of charge from this page, either as a single PDF file (20 MB) or by chapter (click on a "PDF" link below to download a PDF of that section). You will need a software viewer such as Adobe Reader to view the files.

Throughout the chapters of Stem Cells: Scientific Progress and Future Research Directions, the first reference to a Glossary term on a page appears in bold, underlined maroon type. Clicking on the term will open its definition from the Glossary page in a new window.

You can also read the 2006 report, Regenerative Medicine 2006.

Table of Contents

• Front and Back Cover (download as PDF)
• Front Matter (download as PDF)
• Preface (download as PDF)
• Executive Summary (download as PDF)
• Chapter 1: The Stem Cell (download as PDF)
• Chapter 2: The Embryonic Stem Cell (download as PDF)
• Chapter 3: The Human Embryonic Stem Cell and The Human Embryonic Germ Cell (download as PDF)
• Chapter 4: The Adult Stem Cell (download as PDF)
• Chapter 5: Hematopoietic Stem Cells (download as PDF)
• Chapter 6: Autoimmune Diseases and the Promise of Stem Cell-Based Therapies (download as PDF)
• Chapter 7: Stem Cells and Diabetes (download as PDF)
• Chapter 8: Rebuilding the Nervous System with Stem Cells (download as PDF)
• Chapter 9: Can Stem Cells Repair a Damaged Heart? (download as PDF)
• Chapter 10: Assessing Human Stem Cell Safety (download as PDF)
• Chapter 11: Use of Genetically Modified Stem Cells in Experimental Gene Therapies (download as PDF)
• Appendix A: Early Development (download as PDF)
• Appendix B: Mouse Embryonic Stem Cells (download as PDF)
• Appendix C: Human Embryonic Stem Cells and Embryonic Germ Cells (download as PDF)
• Appendix D: Stem Cell Tables (download as PDF)
  1. Published Reports on Isolation and Differentiation of Mouse Stem Cells
  2. Published Reports on Isolation and Differentiation of Human Fetal Tissue Germ Cells
  3. Published Reports on Isolation and Differentiation of Human Embryonic Stem Cells
  4. Published Reports on Isolation and Differentiation of Human Embryonic Carcinoma Stem Cells
  5. Published Reports on Isolation and Differentiation of Human Adult Stem Cells
  6. References
• Appendix E: Stem Cell Markers (download as PDF)
  1. Markers: How Do Researchers Use Them to Identify Stem Cells?
  2. Commonly Used Markers to Identify Stem Cells and Characterize Differentiated Cell Types
• Appendix F: Glossary and Terms (download as PDF)
  1. Glossary
  2. Terms
• Appendix G: Informational Resources (download as PDF)
  1. Persons Interviewed
  2. Special Contributions
  3. Acknowledgments

Reference citations of this report should use the following:

Stem Cells: Scientific Progress and Future Research Directions. Department of Health and Human Services. June 2001. <http://stemcells.nih.gov/info/scireport/2001report>.