Benazepril for Advanced Chronic Renal Insufficiency

This study has been terminated.

Sponsored by:	Southern Medical University, China
Information provided by:	Southern Medical University, China
ClinicalTrials.gov Identifier:	NCT00270426

Purpose

The purpose of this study is to further determine whether benazepril, could safely slow the progression of renal dysfunction in non-diabetic patients with advanced renal insufficiency.

Condition	Intervention
Chronic Kidney Failure	Drug: Benazepril

MedlinePlus related topics: Kidney Failure

Drug Information available for: Benazepril Benazepril hydrochloride

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study

Eligibility

Ages Eligible for Study:	18 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

serum creatinine concentration 1.5-5.0 mg/dL (133-442 µmol/L)
creatinine clearance 20 to70 mL/min/1.73 m2, with variations of less than 30 percent in the three months before the screening evaluation
non-diabetic renal disease
persistent proteinuria (defined as urinary protein excretion greater than 0.3 g/day for three or more months without evidence of urinary-tract infection or overt heart failure [New York Heart Association class III–IV]).

Exclusion Criteria:

immediate need for dialysis; treatment with corticosteroids, non-steroidal anti-inflammatory drugs or immunosuppressive drugs; renovascular disease; myocardial infarction or cerebrovascular accident in the year preceding the trial; connective-tissue disease; obstructive uropathy.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00270426

Sponsors and Collaborators

Southern Medical University, China

Investigators

Principal Investigator:

Fan Fan Hou, M.D.,Ph.D.

Southern Medical University

More Information

Publications of Results:

Hou FF, Zhang X, Zhang GH, Xie D, Chen PY, Zhang WR, Jiang JP, Liang M, Wang GB, Liu ZR, Geng RW. Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med. 2006 Jan 12;354(2):131-40.

Study ID Numbers:	SouthernMUC
Study First Received:	December 23, 2005
Last Updated:	May 4, 2006
ClinicalTrials.gov Identifier:	NCT00270426
Health Authority:	China: State Food and Drug Administration

Keywords provided by Southern Medical University, China:

Advanced Chronic Renal Insufficiency
Benazepril

Study placed in the following topic categories:

Renal Insufficiency
Urologic Diseases
Renal Insufficiency, Chronic
Benazepril

Kidney Failure, Chronic
Kidney Diseases
Kidney Failure

Additional relevant MeSH terms:

Molecular Mechanisms of Pharmacological Action
Therapeutic Uses
Angiotensin-Converting Enzyme Inhibitors
Enzyme Inhibitors

Cardiovascular Agents
Antihypertensive Agents
Pharmacologic Actions
Protease Inhibitors

ClinicalTrials.gov processed this record on January 16, 2009