Relationship of Peritoneal Solute Transport Rate With VEGF in Children Undergoing Peritoneal Dialysis

This study is currently recruiting participants.

Verified by Samsung Medical Center, December 2006

Sponsored by:	Samsung Medical Center
Information provided by:	Samsung Medical Center
ClinicalTrials.gov Identifier:	NCT00516061

Purpose

Vascular endothelial growth factor(VEGF) appears to play a central role in the process leading to peritoneal angiogenesis and increased level of VEGF may contribute to high peritoneal small-solute transport rate (PSTR) in continuous ambulatory peritoneal dialysis (CAPD) patients in adult. In children, lymphatic absorption of solute is greater than adult. VEGF-C is related to lymphogenesis, but its role in peritoneal solute transport rate is not known. In this study, we evaluated possible relationship between dialysate VEGF and VEGF-C levels and PSTR in children.

Condition
Peritoneal Dialysis

MedlinePlus related topics: Kidney Failure

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Defined Population, Retrospective/Prospective Study

Further study details as provided by Samsung Medical Center:

Estimated Enrollment:	40
Study Start Date:	December 2006
Estimated Study Completion Date:	December 2007

Detailed Description:

There was significant correlation between dialysate VEGF165 and VEGF-C levels and significant correlation was noted between dialysate VEGF165 and PSTR. Interestingly, dialysate VEGF-C levels had significant correlation with PSTR. High PSTR seems to be related to elevated VEGF-C and VEGF.

Eligibility

Ages Eligible for Study:	1 Year to 18 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

chronic renal failure
children
peritoneal dialysis

Exclusion Criteria:

acute illness

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00516061

Contacts

Contact: Kyung Hoon Paik, M.D.

82-2-3410-1284

drwhite@skku.edu

Locations

Korea, Republic of
Samsung Medical Center	Recruiting
Seoul, Korea, Republic of, 135-710
Contact: Kyung Hoon Paik, M.D. 82-2-3410-1284 drwhite@skku.edu

Sponsors and Collaborators

Samsung Medical Center

Investigators

Principal Investigator:

Kyung Hoon Paik, M.D.

Samsung Medical Center, Sungkyunkwan University School of Medicine

More Information

Study ID Numbers:	2006-12-008
Study First Received:	August 13, 2007
Last Updated:	August 13, 2007
ClinicalTrials.gov Identifier:	NCT00516061
Health Authority:	South Korea: Institutional Review Board

ClinicalTrials.gov processed this record on January 16, 2009