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Sponsored by: |
National Cancer Institute (NCI) |
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Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00353132 |
RATIONALE: Exposure to trichloroethylene in the workplace may increase the risk of damaging white blood cells. Learning about the long-term effects of trichloroethylene exposure in factory workers in Guangdong Province, China, may help doctors learn more about the risks of this substance.
PURPOSE: This clinical trial is studying exposure to trichloroethylene in factory workers in Guangdong Province, China.
Condition | Intervention |
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Health Status Unknown |
Procedure: cytogenetic analysis Procedure: laboratory biomarker analysis Procedure: molecular diagnostic method Procedure: questionnaire administration Procedure: study of high risk factors |
Study Type: | Observational |
Official Title: | A Cross-Sectional Study of Occupational Exposure to Trichloroethylene, Chromosomal Aberrations, and Related Biomarkers in Guangdong, China |
Estimated Enrollment: | 120 |
Study Start Date: | June 2006 |
OBJECTIVES:
Primary
Secondary
OUTLINE: Participants wear small instruments at work that measure chemicals in the air for 1 or 2 days during the 2-week study period to assess the trichloroethylene exposure levels quantitatively. Participants who have been exposed to trichloroethylene also wear several small skin patches on 1 of the 2 days. Participants also complete a questionnaire related to other exposure information (e.g., work information, smoking and drinking habits, use of medicines, medical history, general health, hobbies, and exposure to radiation and other substances at home). Blood and urine samples are collected to assay a series of biomarkers of susceptibility and to determine intermediate and early biologic effects.
Ages Eligible for Study: | 20 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Factory workers from 3 factories in Guangdong Province, China exposed to trichloroethylene (TCE) in the workplace while working for ≥ 1 year doing the same job in the same part of the manufacturing process and meeting the following criteria:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Study ID Numbers: | CDR0000553301, NCI-06-C-N176, 999906176 |
Study First Received: | July 14, 2006 |
Last Updated: | December 13, 2008 |
ClinicalTrials.gov Identifier: | NCT00353132 |
Health Authority: | United States: Federal Government |
health status unknown |
Chromosomal abnormalities Chromosome Aberrations Trichloroethylene |
Anesthetics, Inhalation Anesthetics, General Therapeutic Uses Physiological Effects of Drugs |
Central Nervous System Depressants Anesthetics Central Nervous System Agents Pharmacologic Actions |