Ocular Hypertension Treatment Study (OHTS)

This study has been completed.

Sponsors and Collaborators:	The New York Eye & Ear Infirmary National Eye Institute (NEI)
Information provided by:	The New York Eye & Ear Infirmary
ClinicalTrials.gov Identifier:	NCT00803998

Purpose

The Ocular Hypertension Treatment Study is a multi-center clinical trial sponsored by the National Eye Institute, designed to determine the efficacy and safety of topically administered eye lowering medication

Condition
Ocular Hypertension Glaucoma

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Glaucoma High Blood Pressure

U.S. FDA Resources

Study Type:	Observational
Official Title:	Ocular Hypertension Treatment Study

Further study details as provided by The New York Eye & Ear Infirmary:

Study Start Date:	February 1994
Estimated Study Completion Date:	December 2006

Eligibility

Ages Eligible for Study:	40 Years to 80 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Qualifying IOP in at least one eye of each participant must be more than or equal 24 mmHg but less than or equal to 32 mm HG calculated from two separate consecutive determination taken at least 2 hours, but not greater than 12 weeks apart.
Normal and reliable 30-2 Humphrey Visual Fields in both eyes.
Normal Optic disc in both eyes on clinical examinations and stereoscopic photographs as determined by the Optic Disc Reading Center.

Exclusion Criteria:

Visual acuity worse than 20/40 in either eye on qualifying exam.
Previous intraocular surgery: laser trabeculoplasty, laser iridotomy, filtering surgery, combined cataract extraction/filtering procedures, penetrating keratoplasty and retinal detachment repair.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00803998

Sponsors and Collaborators

The New York Eye & Ear Infirmary

National Eye Institute (NEI)

Investigators

Study Chair:

Michael Kass, MD

Washington University School of Medicine at St. Louis, St. Louis, Missouri

More Information

Official website for Ocular Hypertension Treatment Study This link exits the ClinicalTrials.gov site

Publications:

Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Kass MA. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002 Jun;120(6):714-20; discussion 829-30.

Study ID Numbers:	93.01
Study First Received:	December 5, 2008
Last Updated:	December 5, 2008
ClinicalTrials.gov Identifier:	NCT00803998
Health Authority:	United States: Institutional Review Board

Study placed in the following topic categories:

Glaucoma
Eye Diseases
Vascular Diseases
Hypertension
Ocular Hypertension

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009