Inclusion Criteria:

• A clinical diagnosis of definite or probable IBM.
• Male or female aged 18-80.
• Subjects must be able to provide informed consent.
• Subjects must be on no immunosuppressive medication for 3 months and agree not to take immunosuppressive medication during the study.
• Subjects must not be on sulfasalazine
• Subjects or caregivers must be able to administer SQ medication.
• Women of childbearing potential (not postmenopausal or surgically sterile) must have a negative pregnancy test at screening and be using adequate birth control.
• Absence of exclusion criteria.

Exclusion Criteria:

• Exposure to etanercept within 3 months of study entry
• Exposure to other investigational drugs within 3 months of study entry.
• Subject with known hypersensitivity to etanercept.
• Subject with active medical or psychiatric condition that in the opinion of the principal investigator, may affect the interpretation of the safety and efficacy data or which otherwise contraindicates participation in the study.
• Signs, symptoms or laboratory evidence of severe renal, pulmonary, hepatic, neurologic, or cardiac (congestive heart failure, or coronary artery) disease, including creatinine > 2.0, LFT > 2x the upper limit of normal and hemoglobin < 12.5 (male) and < 11.0 (female).
• Subject with weakness from any other neurological or neuromuscular disease, including multiple sclerosis or other CNS demyelinating disease.
• Subject with sepsis or any active, chronic, or local infection or on antibiotic, antiviral or antifungal medication within 3 months prior to the first dose of Etanercept.
• A prior history of tuberculosis and/or a positive PPD skin test at screening (including reading of borderline, reactive but non-diagnostic) or prior inoculated subjects.
• Human immunodeficiency virus infection.
• Subject with history of opportunistic infection.
• Subject with a known history of anti-Jo-1, anti-SRP or anti-MI-2 antibodies.
• The presence of an associated connective tissue disease, including systemic lupus erythematous, Sjögren's syndrome, scleroderma or mixed connective tissue disease.
• History of a new diagnosis or treatment of invasive malignancy within 5 years of enrollment. Patients with a history of treated squamous cell carcinoma or basal cell carcinoma limited to the skin are not excluded.
• History of drug or alcohol abuse within 1 year prior to study entry.
• Unwillingness to practice effective contraception, except for female patients who are post-menopausal or surgically sterile. The rhythm method is not to be used as the sloe method of contraception.
• Subjects are not to receive live vaccines while in the study.