Option 1
Option 2
Option 3
Submit complete multicenter Phase III Definitive Clinical Trial application. A detailed Manual of Procedures (MOP) must be submitted as an Appendix to the application.
![Arrow pointing down](https://webarchive.library.unt.edu/eot2008/20090113192936im_/http://www.nidcd.nih.gov/staticresources/images/arrowdown_green.gif)
Reviewed by NIDCD Peer Review Group
![Arrow pointing down](https://webarchive.library.unt.edu/eot2008/20090113192936im_/http://www.nidcd.nih.gov/staticresources/images/arrowdown_green.gif)
Reviewed by National Deafness and Other Communication Disorders Advisory Council
Submit a NIDCD Clinical Trial Planning Grant
![Arrow pointing down](https://webarchive.library.unt.edu/eot2008/20090113192936im_/http://www.nidcd.nih.gov/staticresources/images/arrowdown_green.gif)
Submit complete multicenter Phase III Definitive Clinical Trial application. A detailed Manual of Procedures (MOP) must be submitted as an Appendix to the application.
![Arrow pointing down](https://webarchive.library.unt.edu/eot2008/20090113192936im_/http://www.nidcd.nih.gov/staticresources/images/arrowdown_green.gif)
Reviewed by NIDCD Peer Review Group
![Arrow pointing down](https://webarchive.library.unt.edu/eot2008/20090113192936im_/http://www.nidcd.nih.gov/staticresources/images/arrowdown_green.gif)
Reviewed by National Deafness and Other Communication Disorders Advisory Council
Submit Preliminary (Phase I and/or Phase II) Clinical Trial Application
![Arrow pointing down](https://webarchive.library.unt.edu/eot2008/20090113192936im_/http://www.nidcd.nih.gov/staticresources/images/arrowdown_green.gif)
Reviewed by NIDCD Peer Review Group
![Arrow pointing down](https://webarchive.library.unt.edu/eot2008/20090113192936im_/http://www.nidcd.nih.gov/staticresources/images/arrowdown_green.gif)
![Arrow pointing down](https://webarchive.library.unt.edu/eot2008/20090113192936im_/http://www.nidcd.nih.gov/staticresources/images/arrowdown_green.gif)
Follow Path of Option 1
![Arrow pointing down](https://webarchive.library.unt.edu/eot2008/20090113192936im_/http://www.nidcd.nih.gov/staticresources/images/arrowdown_green.gif)
Follow Path of Option 2