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REDOX BIOLOGY FINAL EXAMINATION (NOVEMBER 25, 2008)

Numerous students have requested a certificate upon completion of the Redox Biology (RB) course.  In order to obtain the certificate you must answer 10 of the 14 questions correctly.  In the final examination, 1 questions are derived from each of the 1 hour lectures.  It is highly recommended that you have a copy of each powerpoint presentation prior to taking the examination. 

For the following 14 questions, please provide the best lettered answer for the numbered question:  If a is the best answer, click (a).  If b is the best answer, click (b).  If c is the best answer, click (c).  If a, b and c are correct, click (d).  If neither a,b or c are correct, click (e).  You may choose only one lettered answer for each 14 numbered questions.  There is no time limit of the examination, however, it must be completed in one setting, so you cannot save your work.  The exam is open-book and open-notes.  Good luck.



Full Name: (to appear on your certificate)

  1. Soluble guanylate cyclase:
    A  is dimer
    B  Has heme groups
    C  is nitrosylated by NO
    D  all of the above
    E  none of the above

  2. Superoxide dismutase:
    A  metabolizes hydroxyl radicals
    B  is increased in many cancers
    C  has allelic variations which increase cancer risk
    D  all of the above
    E  none of the above

  3. H2O2 is a product of which enzyme(s)?
    A  Glucose oxidase
    B  Polyamine oxidase
    C  Xanthine Oxidase
    D  all of the above
    E  none of the above

  4. CNS vasospasm is reduced by:
    A  Nitrite
    B  Hydrogen peroxide
    C  Methionine
    D  all of the above
    E  none of the above

  5. Catalase
    A  is a tumor suppressor gene
    B  promotes cellular differentiation
    C  metabolizes hydrogen peroxide
    D  all of the above
    E  none of the above

  6. HIF-1α expression:
    A  is increased by prolylhydroxylase
    B  is increased by reactive nitrogen species
    C  is unaltered by reactive oxygen species
    D  all of the above
    E  none of the above

  7. Reactive oxygen species:
    A  cause lipid peroxidation
    B  causes DNA strand breaks
    C  causes protein nitration
    D  all of the above
    E  none of the above

  8. Interferon-γ:
    A  is essential for interleukin-12 induced tumor regression
    B  has no effect on iNOS expression
    C  expression is unaffected by ARE in 3’ untranslated region
    D  all of the above
    E  none of the above

  9. Which technique uses radioisotopes e.g. 18F?
    A  MRI
    B  CT
    C  PET
    D  all of the above
    E  none of the above

  10. Tempol:
    A  increases radiation sensitivity
    B  is a radioprotector
    C  increased superoxide concentrations
    D  all of the above
    E  none of the above

  11. NSAIDs:
    A  increase phase 1 activation enzymes e.g. CYP1A
    B  decrease glutathione
    C  increase carcinogenesis
    D  all of the above
    E  none of the above

  12. NADPH oxidases:
    A  generate reactive oxygen species
    B  have a heme
    C  cross the plasma membrane several times
    D  all of the above
    E  none of the above

  13. Thrombospondin:
    A  increases angiogenesis
    B  inhibits p38 MAP kinase
    C  decreases apoptosis
    D  all of the above
    E  none of the above

  14. Inflammation associated cancer can be influenced by:
    A  Enhanced NOS2 expression
    B  Formation of reactive nitrogen species
    C  macrophages
    D  all of the above
    E  none of the above


    Please review your answers and make any changes that needed. If you are done, please submit your answers and your exam will be computer graded. If you answer 10 of the questions correct, you will be forwarded to the course evaluation.

RB Examination is currently Closed.