Chief, Immunopathology Section, ODIR
NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 30 ROOM 3A-300
30 CONVENT DR MSC 4352
BETHESDA MD 20892-4352
Phone: (301) 496-9219
Fax: (301) 402-1064
E-mail: Larry Wahl
Research Interests
Regulation of connective tissue metabolism by the immune system; signal transduction; matrix metalloproteinases; cytokines; prostaglandins; extracellular matrix molecules; inflammatory mediators.
Education
1965: B.S., Zoology, Seattle Pacific University, Seattle, Washington
1972: Ph.D., Dept. of Biological Structure, School of Medicine, University of Washington, Seattle, Washington
Selected Recent publications
Zhang, Y., D. L. DeWitt, T. B. McNeely, S. M. Wahl, and L. M. Wahl. 1997. Secretory leukocyte protease inhibitor (SLPI) suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2 and matrix metalloproteinases. J. Clin. Invest. 99: 894-900.
Shankavaram, U. T., D. L. DeWitt, S. E. Funk, E. H. Sage, and L. M. Wahl. 1997.Regulation of human monocyte matrix metalloproteinases by SPARC. J. Cell. Physiol. 173:327-334.
Zhang, Y., K. McCluskey, K. Fujii, and L. M. Wahl. 1998. Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNFa, GM-CSF, and IL-1b through prostaglandin dependent and independent mechanisms. J. Immunol. 161:3071-3076.
Shankavaram, U. T., D. L. DeWitt, and L. M. Wahl. 1998. Lipopolysaccharide induction of monocyte matrix metalloproteinases is regulated by tyrosine phosphorylation of cytosolic phospholipase A2. J. Leukoc. Biol. 64:221-227.
Wahl, L. M. and H. K. Kleinman. 1998. Tumor associated macrophages as targets for cancer therapy. J. Natl. Cancer Inst. 90:1583-1584.
Suttles, J., D. M. Milhorn, R. W. Miller, J. C. Poe, L. M. Wahl, and R. D. Stout. 1999 CD40 stimulation of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway: a target of IL-4 and IL-10 anti inflammatory action. J. Biol. Chem. 274:5835-5842.
Karp, C. L., A. Grupe, E. Schadt, S. L. Ewart, M. Keane-Moore, P. J. Cuomo, J. KÖhl, L. Wahl, D. Kuperman, S. Germer, D. Aud, G. Peltz, and M. Wills-Karp. 2000. Identification of complement factor 5 (C5) as a susceptibility locus for experimental allergic asthma. Nature Immunol. 3:221-226.
Shankavaram, U. T., W. C. Lai, S. Netzel-Arnett, P. R. Mangan, J. A. Ardans, N. Caterina, W. G. Stetler-Stevenson, H. Birkedal-Hansen, and L. M. Wahl. 2001. Monocyte membrane type 1-matrix metalloproteinase: prostaglandin-dependent regulation and role in MMP-2 activation. J. Biol. Chem. 276:19027-19032.
Ardans, J. A., A. Blum, P. R. Mangan, S. Wientroub, R. O. Cannon III, and L. M Wahl. 2001. Raloxifene-mediated increase in matrix metalloproteinase-1 production by activated monocytes. Aterioscler. Throm. Vasc. Biol. 21:1265-1268.
Ardans, J. A., A. P. Economou, J. M. Martinson, Jr., M. Zhou, and L. M. Wahl. 2002. Oxidized low-density and high-density lipoproteins regulate the production of matrix metalloproteinase-1 and –9 by activated monocytes. J. Leukoc. Biol. 71:1012-1018.
Lai, W-C, M. Zhou, U. Shankavaram, G. Peng and L. M. Wahl. 2003. Differential regulation of lipopolysaccharide induced monocyte MMP-1 and MMP-9 by p38 and ERK 1/2 MAP kinases. J. Immunol. 170:6244-6249.
Zhou, M., Y. Zhang, J. A. Ardans and L. M. Wahl. 2003 Interferon-g differentially regulates monocyte matrix metalloproteinase-1 and -9 through tumor necrosis factor-a and caspase8. J. Biol. Chem. 278:45406-45413.
Mukundan, L., G. A. Bishop, K. Z. Head, L. Zhang, L. M. Wahl, and J. Suttles. 2005. TNF receptor-associated factor 6 is an essential mediator of CD40 activated proinflammatory pathways in monocytes and macrophages. J. Immunol. 174:1081-1090.
Kim, M. P, C. A. Gaydos, B. J. Wood, J. P. Hardick, Y. Zhang, and L. M. Wahl. 2005. Chlamydia pneumonia enhances cytokine stimulated human monocyte matrix metalloproteinases through a PGE2-dependent mechanism. Infect. Immun. 73:632-634.
Kim, M.P, M. Zhou and L. M. Wahl. 2005. Angiotensin II increases human monocyte matrix metalloproteinase 1 through the AT2 receptor and prostaglandin E2: Implications for Atherosclerotic Plaque Rupture. J. Leukoc. Biol. 78:195-201.
Lu, Y. and L. M. Wahl. 2005. Production of matrix metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3kinase/Akt/IKKα/NF-κB pathway. J. Leukoc. Biol. 78:259-265.
Lu, Y. and L. M. Wahl. 2005. Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF-κB activity in lipopolysaccharide-activated human primary monocytes. J. Immunol. 175:5423-5429.
Zhang, Y. and L. M. Wahl. 2006. Synergistic enhancement of cytokine-induced human monocyte matrix metalloproteinase-1 by C-reactive protein and oxidized LDL through differential regulation of monocyte chemotactic-1 and prostaglandin E2. J. Leukoc. Biol. 79:105-113.
Philp, D., B. Scheremeta, K. Sibliss, M. Zhou, E. L. Fine, M. Nguyen, L. Wahl, M. P. Hoffman, and H. K. Kleinman. 2006. Thymosin beta 4 promotes matrix metalloproteinase expression during wound repair. J. Cell. Physiol. 208:195-200.
Kim, M. P., L. M. Wahl, L. R. Yanek, D. M. Becker, and L. C. Becker. 2007 Monocyte chemoattractant protein-1 A(-2518)G polymorphism is associated with occult ischemia in a high-risk asymptomatic population. Atherosclerosis, in press.
Zhou, Z.H., Y. Zhang, Y. F. Hu, L. M. Wahl, J. O. Cisar, and A. L. Notkins. 2007 The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies. Cell Host and Microbe. in press.