The Molecular Basis of Memory Loss in Transgenic Models of Alzheimer's Disease |
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| Launch in standalone player | |
| Air date: | Monday, May 12, 2008, 12:00:00 PM |
| Category: | Neuroscience |
| Runtime: | 75 minutes |
| NLM Title: | The molecular basis of memory loss in transgenic models of Alzheimer's disease [electronic resource] / Karen Hsiao Ashe. |
| Series: | NIH neuroscience seminar series |
| Author: | Ashe, Karen Hsiao. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2008] |
| Other Title(s): | NIH neuroscience seminar series |
| Abstract: | (CIT): Dr. Ashe's research addresses the molecular basis of memory loss and cognitive dysfunction in Alzheimer's disease. The studies involve the creation of transgenic mouse models of Alzheimer's disease in order to understand how the amyloid-[beta] and tau proteins impair memory and cognition. The work has shown that the aggregates of amyloid-[beta] and tau proteins which define Alzheimer's disease neuropathologically do not cause cognitive deficits in mice. These investigations have led to the discovery of a form of the amyloid-[beta] protein called A[beta] star (A[beta]*) that disrupts cognitive function in mice and rats, and revealed a potential mechanism by which interactions with a neuronal receptor may impair memory. |
| Subjects: | Alzheimer Disease--complications Alzheimer Disease--pathology Alzheimer Disease--physiopathology Disease Models, Animal Memory Disorders--etiology Memory Disorders--pathology Memory Disorders--physiopathology Mice, Transgenic |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WT 155 |
| NLM ID: | 101475710 |
| CIT File ID: | 14488 |
| CIT Live ID: | 6190 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14488 |
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Enhanced Audio Podcast | 1:04:23 |
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Enhanced Video Podcast | 1:04:23 | |