Linking Molecular Motors to Signaling and Neurodegenerative Disease |
|
|---|---|
|
|
|
| Launch in standalone player | |
| Air date: | Monday, May 08, 2006, 12:00:00 PM |
| Category: | Neuroscience |
| Runtime: | 75 minutes |
| NLM Title: | Linking molecular motors to signaling and neurodegenerative disease [electronic resource] / Larry Goldstein. |
| Series: | NIH neuroscience seminar series |
| Author: | Goldstein, Larry B. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2006] |
| Other Title(s): | NIH neuroscience seminar series |
| Abstract: | (CIT): Dr. Goldstein's laboratory is interested in understanding the molecular mechanisms of intracellular movement and the role of transport dysfunction in neurodegenerative diseases. The major questions they are addressing are: 1. What role(s) do these motors play in axonal and dendritic transport, transport of visual system components in photoreceptors, and transport of informational signaling molecules? 2. Does motor-driven transport dysfunction play a major role in neurodegenerative diseases such as retinitis pigmentosum, amyotrophic lateral sclerosis (Lou Gehrigs disease), Huntingtons Disease and Alzheimers disease? 3. How are kinesins and dyneins coupled to intracellular cargoes and regulated? 4. How are appropriate destinations in the neuron found (e.g., axons versus dendrites)? 5. Do intracellular transport processes play important roles in neuronal cell polarization, signaling, growth, and pathfinding? |
| Subjects: | Molecular Motor Proteins--physiology Neurodegenerative Diseases Neurons--physiology |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WL 359 |
| NLM ID: | 101285762 |
| CIT File ID: | 13221 |
| CIT Live ID: | 4384 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13221 |