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Sponsored by: |
University Hospital Muenster |
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Information provided by: | University Hospital Muenster |
ClinicalTrials.gov Identifier: | NCT00148161 |
The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.
Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.
Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.
The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.
Condition |
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Stuttering |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Defined Population, Prospective Study |
Official Title: | Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Antoinette G Dinnesen, Prof. Dr. | +49(0)251 83 ext 56859 | a.g.dinnesen@uni-muenster.de |
Contact: Arne Knief, Dr. | +49(0)251 83 ext 56886 | knief@uni-muenster.de |
Germany | |
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster | Recruiting |
Münster, Germany, 48161 | |
Contact: Antoinette G Dinnesen, Prof. Dr. +49(0)251 83 ext 56859 a.g.dinnesen@uni-muenster.de | |
Principal Investigator: Antoinette G Dinnesen, Prof. Dr. | |
Principal Investigator: Arne Knief, Dr. | |
Sub-Investigator: Michael Schneider | |
Institute for Biomagnetism and Biosignalanalysis | Recruiting |
Münster, Germany, 48149 | |
Contact: Christo Pantev, Prof. Dr. +49(0)251 83 ext 56865 pantev@uni-muenster.de | |
Principal Investigator: Christo Pantev, Prof. Dr. |
Study Director: | Antoinette G Dinnesen, Prof. Dr. | Department of Phoniatrics and Pediatric Audiology, University Hospital Münster |
Principal Investigator: | Arne Knief, Dr. | Department of Phoniatrics and Pediatric Audiology, University Hospital Münster |
Study ID Numbers: | phonpaed001 |
Study First Received: | September 6, 2005 |
Last Updated: | April 26, 2007 |
ClinicalTrials.gov Identifier: | NCT00148161 |
Health Authority: | Germany: Ethics Commission |
Magnetoencephalography Auditory cortex Stuttering Non stuttering |
Signs and Symptoms Speech Disorders Neurologic Manifestations Language Disorders |
Stuttering Neurobehavioral Manifestations Communication Disorders |
Nervous System Diseases |