Chief, Laboratory of Cell and Developmental Biology
NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 30, ROOM 426
30 CONVENT DR MSC 4370
BETHESDA MD 20892-4370
Phone: (301) 496-9124
Fax: (301) 402-0897
E-mail: Dr. Kenneth M. Yamada
Research Interests
Mechanisms and regulation of cell adhesion, migration, and invasion; cell surface interactions in embryonic development, wound repair, and cancer; fibronectin and other extracellular matrix molecules; integrins; signal transduction; membrane-cytoskeletal interactions and regulation.
Education
1966: BA, Biological Sciences, Stanford University, Palo Alto, California
1971: PhD, Biological Sciences, Stanford University
1972: MD, Stanford University School of Medicine
Recent publications
Pankov, R., Cukierman, E., Katz, B.-Z., Matsumoto, K., Lin, D.C., Lin, S., Hahn, C., and Yamada, K.M. Integrin dynamics and matrix assembly: Tensin-dependent translocation of alpha5-beta1 integrins promotes early fibronectin fibrillogenesis. J. Cell Biol. 148: 1075-1090, 2000.
Danen, E.H.J., Sonneveld, P., Sonnenberg, A., and Yamada, K.M. Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor–stimulated cell cycle progression. J. Cell Biol. 151: 1413-1422, 2000.
Cukierman, E., Pankov, R., Stevens, D.R., and Yamada, K.M. Taking cell-matrix adhesions to the third dimension. Science 294: 1708-1712, 2001.
Pankov, R., Cukierman, E., Clark, K., Matsumoto, K., Hahn, C., Poulin, B., and Yamada, K.M. Specific beta-1 integrin site regulates Akt/PKB signaling via local activation of PP2A. J. Biol. Chem. 278: 18671-18681, 2003.
Sakai, T., Larsen, M., and Yamada, K.M. Fibronectin requirement in branching morphogenesis. Nature 423: 876-881, 2003.
Rossner, M., and Yamada, K. What’s in a picture? The temptation of image manipulation. J. Cell Biol. 166: 11-15, 2004.
Pankov, R., Endo, Y., Even-Ram, S., Araki, M., Clark, K., Cukierman, E., Matsumoto, K., and Yamada, K.M. A Rac switch regulates random versus directionally persistent cell migration. J. Cell Biol. 170: 793-802, 2005.
Larsen, M., Wei, C., and Yamada, K.M. Cell and fibronectin dynamics during branching morphogenesis. J. Cell Sci. 119: 3376-3384, 2006.
Galbraith, C.G., Yamada, K.M., and Galbraith, J.A. Polymerizing actin fibers position integrins primed to probe for adhesion sites. Science 315: 992-995, 2007.
Even-Ram, S., Doyle, A.D., Conti, M.A., Matsumoto, K., Adelstein, R.S., and Yamada, K.M. Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. Nature Cell Biol. 9: 299-309, 2007.
Wei, C., Larsen, M., Hoffman, M.P., and Yamada, K.M. Self-organization and branching morphogenesis of primary salivary epithelial cells. Tissue Engineering 13: 721-735, 2007.
Yamada K.M., and Cukierman, E. Modeling tissue morphogenesis and cancer in 3D. Cell 130: 601-610, 2007.
Complete CV and Publications
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