Architecture and Mechanism at Chemical Synapses |
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| Launch in standalone player | |
| Air date: | Monday, April 07, 2008, 12:00:00 PM |
| Category: | Neuroscience |
| Runtime: | 75 minutes |
| NLM Title: | Architecture and mechanism at chemical synapses [electronic resource] / Eric Gouaux. |
| Series: | NIH neuroscience seminar series |
| Author: | Gouaux, Eric. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2008] |
| Other Title(s): | NIH neuroscience seminar series |
| Abstract: | (CIT): The work in the Gouaux Lab is concentrated on developing atomic scale mechanisms for the function of receptors and transporters at chemical synapses. At chemical synapses, neurotransmitters released from one neuron diffuse throughout a small space--the synaptic cleft--to receptors on adjacent neurons. At many synapses, the neurotransmitter binds to a receptor that is a ligand-gated ion channel, and this binding event leads to the opening of a transmembrane pore, which in turn results in depolarization of the nerve cell and generation of an electrical signal. Neurotransmitter transporters surrounding the synapse clear the transmitters from the cleft by coupling the thermodynamically unfavorable uptake to the favorable co-transport of one or more sodium ions. Glutamate, glycine and the biogenic amines are neurotransmitters of particular significance and currently they are focusing their efforts on eukaryotic glutamate receptors and on bacterial homologs of the transporters for glutamate, glycine and the biogenic amines. While their primary tool is x-ray crystallography, they also utilize electrophysiology as well as other biophysical and biochemical methods. |
| Subjects: | Neurons--physiology Neurotransmitter Agents--physiology Synapses--chemistry Synapses--physiology Synaptic Transmission--physiology |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WL 102.8 |
| NLM ID: | 101473071 |
| CIT File ID: | 14410 |
| CIT Live ID: | 6185 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14410 |
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Enhanced Audio Podcast | 1:05:42 |
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Enhanced Video Podcast | 1:05:42 | |