Psychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure - Full Text View

Sponsored by:	National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00255411

Purpose

This study will explore how the mind and the brain work to cause movement symptoms or seizures in people who do not have a recognized neurological or medical disorder. The study includes a check for psychiatric disorders, symptoms and their severity; psychiatric and personality questionnaires; and neuropsychological testing.

Normal, healthy volunteers, people who have movement symptoms not due to a brain or medical disorder and people who have seizures not due to epilepsy may be eligible for this study. All candidates must be 18 years of age or older.

All participants have a medical history, physical examination and psychological evaluation, including completion of questionnaires. People with movement symptoms or seizures have a symptoms evaluation.

Some participants also undergo neuropsychological testing, including questionnaires, pen-and-paper or computerized tests, and motor tasks.

Condition
Psychogenic Movement Disorders Non-Epileptic Seizures

Genetics Home Reference related topics: familial paroxysmal nonkinesigenic dyskinesia pyridoxal 5'-phosphate-dependent epilepsy pyridoxine-dependent epilepsy

MedlinePlus related topics: Movement Disorders Seizures

U.S. FDA Resources

Study Type:	Observational
Official Title:	Neuropsychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	190
Study Start Date:	November 2005

Detailed Description:

Objectives

The objectives of this study are (1) to investigate the relationship between childhood abuse and dissociative experiences in both psychogenic movement disorders (PMD) and non-epileptic seizures (NES) and (2) to investigate the relationship between childhood abuse and both PMD and NES. The secondary objective of the study is to investigate if measures of response inhibition differ between PMD subjects compared to normal controls. This study is part of a larger study investigating the psychological and biological correlates of conversion disorder.

Study population

We intend to study adult patients with diagnoses of PMD seen by the Human Motor Control Section clinic or patients with diagnoses of NES seen by the Epilepsy clinic and normal controls.

Design

A psychiatric assessment, measurement scales and neuropsychological testing will be administered to the PMD and NES patients and normal controls.

Outcome measures

The first primary outcome measure will be the comparison of the different subtypes of childhood abuse (as measured by the Childhood Trauma Interview) and the severity of dissociation (as measured by the Dissociative Experiences Scale). The second primary outcome measure will be the comparison of frequencies of different subtypes of childhood abuse (as measured by the Childhood Trauma Interview) between PMD, NES and normal control groups. The secondary outcome measure will be the comparison of stop-signal reaction time as measured with the stop-signal task.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

INCLUSION CRITERIA:

Patients for dissociation study:

Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist.
Or a diagnosis of NES based on video-EEG. The diagnosis will be made by an epileptologist.
Males or females
Age 18 or older
Able to provide informed consent

Patients for cognitive study:

Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist.
Age 18 or older
Males or females
Able to provide informed consent

Normal volunteers for cognitive study:

Normal volunteers age 18 or older will be included
Males or females
Able to provide informed consent

EXCLUSION CRITERIA:

Patients for dissociation study:

Diagnosis of probable or possible PMD using Fahn and Williams criteria.
Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy.
Patients with a medical condition that prevents them from taking part in the study.
Patients with current suicidal ideation.
Patients with a psychotic disorder.
Patients with active substance abuse within the last 6 months.
Patients below the age of 18.
Patients who are not capable of consent.
Patients with an IQ less than 55.
Patients currently involved in lawsuits.

Patients for cognitive study:

Diagnosis of probable or possible PMD using Fahn and Williams criteria
Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy
Patients with a medical condition that prevents them from taking part in the study.
Patients with a history of a neurological disorder (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits.
Patients with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds.
Patients with a psychotic disorder or bipolar disorder
Patients with a current major depression
Patients with current moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25)
Patients with current attention deficit hyperactivity disorder.
Patients with active substance abuse within the last 6 months.
Patient with current suicidal ideation.
Patients below the age of 18.
Patients who are not capable of consent.
Patients with an IQ less than 55.
Patients currently involved in lawsuits.

Normal volunteers for cognitive study:

Normal volunteers younger than 18 years
Normal volunteers with an active medical condition that might prevent participation.
Normal volunteers with a history of neurological disorders (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits
Normal volunteers with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds
Normal volunteers with a psychotic disorder or bipolar disorder
Normal volunteers with a current major depression
Normal volunteers with moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25)
Normal volunteers with active substance abuse within the last 6 months
Normal volunteers with current attention deficit hyperactivity disorder
Normal volunteers with an IQ less than 55
Normal volunteers who are not capable of consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00255411

Contacts

Contact: Patient Recruitment and Public Liaison Office	(800) 411-1222	prpl@mail.cc.nih.gov
Contact: TTY	1-866-411-1010

Locations

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike	Recruiting
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institute of Neurological Disorders and Stroke (NINDS)

More Information

NIH Clinical Center Detailed Web Page This link exits the ClinicalTrials.gov site

Publications:

Williams DT, Ford B, Fahn S. Phenomenology and psychopathology related to psychogenic movement disorders. Adv Neurol. 1995;65:231-57. Review. No abstract available.

Carson AJ, Ringbauer B, Stone J, McKenzie L, Warlow C, Sharpe M. Do medically unexplained symptoms matter? A prospective cohort study of 300 new referrals to neurology outpatient clinics. J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):207-10.

Stone J, Carson A, Sharpe M. Functional symptoms and signs in neurology: assessment and diagnosis. J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1:i2-12. Review. No abstract available.

Study ID Numbers:	060027, 06-N-0027
Study First Received:	November 17, 2005
Last Updated:	July 18, 2008
ClinicalTrials.gov Identifier:	NCT00255411
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Conversion Disorder
Somatoform Disorder
Involuntary Movement
Childhood Abuse
Depression
Psychogenic Movement Disorder

PMD
Non-Epileptic Seizure
NES
Healthy Volunteer
HV

Study placed in the following topic categories:

Depression
Conversion disorder
Seizures
Central Nervous System Diseases
Healthy
Depressive Disorder
Brain Diseases

Hysteria
Signs and Symptoms
Movement Disorders
Epilepsy
Neurologic Manifestations
Somatoform Disorders
Conversion Disorder

Additional relevant MeSH terms:

Pathologic Processes
Disease
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009