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Your search term(s) "Bleeding Disorders" returned 36 results.

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Introduction to Hemophilia. Montreal, Quebec: Canadian Hemophilia Society. 2007. pp 1-20.

This introductory chapter is from a monograph that provides information for female carriers of hemophilia A and B, a type of genetic bleeding disorder traditionally experienced by males but passed on genetically by females. Recent understanding of this disorder shows that females can have the same problems as males with mild hemophilia, such as hemorrhaging after surgery or trauma. Women with clotting factor levels as high as 60 percent can have abnormal bleeding problems, including but not restricted to gynecological and obstetrical bleeding. This chapter answers common questions about who is affected by hemophilia, the number of people affected, the symptoms of hemophilia, the types and severity of hemophilia, other bleeding disorders, blood clotting, the treatments for hemophilia, common complications, the life expectancy of people with hemophilia, and the future of hemophilia care. Treatments discussed including clotting factor therapy, desmopressin acetate for factor VIII deficiency, and antifibrinolytics for both factor VIII and IX deficiency. Complications can include the development of inhibitors, joint disease, gynecological complications, and bloodborne infections. Readers are referred to a more detailed guide for families at www.hemophilia.ca/en/13.1.php.

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Miscellaneous Questions. IN: Roberts, H.R., ed. Haemophilia and Haemostasis: A Case-Based Approach to Management. Williston, VT: Blackwell Publishing Inc. 2007. pp 173-189.

This chapter of miscellaneous topics is from a book that compiles a breadth of questions relating to perplexing or complicated management questions in the fields of hemophilia and hemostasis. The contributing authors have provided practical, hands-on answers to the questions sent in by practitioners in the field. This section discusses bleeding time versus PFA-100, cocaine and DDAVP, hyponatremia and DDAVP, the use of the international normalized ratio (INR) to assess patients both on and not on coumadin, selective serotonin reuptake inhibitors (SSRIs) and clotting disturbances, and the recommended work-up for children with intracranial bleeding. Much of the information is presented through case studies. 18 references.

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Symptomatic Carriers. Montreal, Quebec: Canadian Hemophilia Society. 2007. pp 35-42.

This chapter on symptomatic carriers is from a monograph that provides information for female carriers of hemophilia A and B, a type of genetic bleeding disorder traditionally experienced by males but passed on genetically by females. Recent understanding of this disorder shows that females can have the same problems as males with mild hemophilia, such as hemorrhaging after surgery or trauma. Women with clotting factor levels as high as 60 percent can have abnormal bleeding problems, including but not restricted to gynecological and obstetrical bleeding. This chapter explains why hemophilia carriers have bleeding problems, why some carriers bleed more than others, and what types of bleeding carriers may experience. Specific topics include symptoms, menorrhagia, the process of X-inactivation, and the link between menorrhagia and bleeding disorders. The authors note that approximately 20 percent of carriers are symptomatic to some degree. However, clotting factor VIII and IX levels can range from 5 percent to 200 percent of normal. Carriers of hemophilia experience more spontaneous and unprovoked hemorrhages and the risk is highest in those with the lowest clotting factor levels. 1 table.

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Bleeding Disorders Caused by Vascular and Platelet Abnormalities. IN: Hoffbrand, A.V.; Moss, P.A.H.; Pettit, J.E. Essential Haematology. 5th ed. Williston, VT: Blackwell Publishing Inc. 2006. pp. 278-289.

This chapter on bleeding disorders caused by vascular and platelet abnormalities is from a hematology textbook that offers a comprehensive look at the biochemical, physiological, and immunological processes involved in normal blood cell formation and function and the disturbances that may occur in different diseases. The authors consider vascular bleeding disorders, thrombocytopenia, disorders of platelet function, the diagnosis of platelet disorders, and the use of platelet transfusions. Vascular and platelet disorders tend to be associated with bleeding from mucous membranes and into the skin, whereas in coagulation disorders, the bleeding is often into joints or soft tissue. The chapter features full-color illustrations and photographs. 11 figures. 3 tables. 11 references.

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Bleeding Disorders in Premenopausal Women: (Another) Public Health Crisis for Hematology?. Washington, DC: American Society of Hematology. 2006. pp. 474-485.

This article reviews bleeding disorders in premenopausal women, a potentially major public health problem. The authors note that up to 20 percent of women with menorrhagia may have an underlying bleeding disorder, which is a prevalence of 1.5 to 4 million American women. Von Willebrand disease (VWD) is the most common bleeding disorder among women with menorrhagia, affecting up to 20 percent of such patients. Besides menorrhagia, important complications of bleeding disorders in premenopausal women include iron deficiency anemia, miscarriage, postpartum bleeding, uterine bleeding and hysterectomy. These patients face many obstacles in achieving optimum care. Recognition is difficult as women may consider their symptoms a normal part of their monthly menstrual cycle and thus come to medical attention only after serious bleeding events. Symptoms of VWD may also overlap with benign conditions; primary providers may not suspect the diagnosis, and convenient hematologic input may be unavailable. Diagnosis is difficult as there is no single definitive test for VWD, and test results are variable, often being affected by factors such as stress, contraceptives, hormones, and pregnancy. Hemostatic treatment is limited by DDAVP tachyphylaxis, the lack of recombinant VWD concentrates, and the ineffectiveness of hormonal therapy, leading to unnecessary procedures and early hysterectomy. The authors conclude by discussing the significant controversy that exists regarding classification of type 1 VWD as a disease: given the overlap in symptoms and laboratory assays within the normal population, evaluation for those with VWD might be seen as identification of potential bleeding risk rather than detection of a disease. The authors offer the combined perspectives of the obstetrician-gynecologist and the hematologist to promote a better public health approach to this problem. 8 tables. 60 references.

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Bleeding Disorders. IN: Nilsson, K.R.; Piccini, J.P., eds. Osler Medical Handbook. Philadelphia, PA: Saunders. 2006. pp. 516-525.

This chapter on bleeding disorders is from a handbook that provides the essentials of diagnosis and treatment, as well as the latest in evidence-based medicine, for residents working bedside, in-patient care. The chapter begins with a presentation of essential Fast Facts and concludes with Pearls and Pitfalls useful to the practicing internist. The body of the chapter is divided into sections: Epidemiology, Clinical Presentation, Diagnosis, and Management. Specific topics covered in this chapter include inherited bleeding disorders, such as von Willebrand disease (vWD) and hemophilia; acquired bleeding disorders, which can be caused by liver disease, vitamin K deficiency, and antiplatelet or anticoagulation therapy, among other causes; the symptoms of clinically significant vWD, including mucosal bleeding and easy bruising; the role of family history of bleeding diathesis or a need for chronic transfusions or iron replacement in identifying bleeding disorders; and hemorrhagic death due to cerebral bleeding in patients with hemophilia. The chapter concludes with a list of references, each labeled with a 'strength of evidence' grade to help readers determine the type of research available in that reference source. 5 figures. 1 table. 9 references.

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Coagulation Disorders. IN: Hoffbrand, A.V.; Moss, P.A.H.; Pettit, J.E. Essential Haematology. 5th ed. Williston, VT: Blackwell Publishing Inc. 2006. pp. 290-302.

This chapter on coagulation disorders is from a hematology textbook that offers a comprehensive look at the biochemical, physiological, and immunological processes involved in normal blood cell formation and function and the disturbances that may occur in different diseases. The authors discuss hereditary coagulation disorders, notably hemophilia, and acquired coagulation disorders. Specific topics include hemophilia A, factor IX deficiency, von Willebrand disease, vitamin K deficiency, disseminated intravascular coagulation, coagulation deficiency, and massive transfusion syndrome. A final section describes thromboelastrography, a technique for the global assessment of hemostatic function of a single blood sample in which the reaction of platelets with the protein coagulation cascade is observed. The chapter features full-color illustrations. 10 figures. 6 tables. 22 references.

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Essential Haematology. 5th ed. Williston, VT: Blackwell Publishing Inc. 2006. 380 p.

This hematology textbook offers a comprehensive look at the biochemical, physiological, and immunological processes involved in normal blood cell formation and function and the disturbances that may occur in different diseases. The book is designed to help medical students grasp the essential features of modern clinical and laboratory hematology. The book includes 28 chapters on hemopoiesis, erythropoiesis and general aspects of anemia, hypochromic anemias and iron overload, megaloblastic anemias and other macrocytic anemias, hemolytic anemias, genetic disorders of hemoglobin, granulocytes and monocytes, lymphocytes and their benign disorders, the spleen, the etiology and genetics of hematological malignancies, the management of hematological malignancy, acute leukemias, chronic myeloid leukemia, myelodysplasia, the chronic lymphoid leukemias, Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, multiple myeloma and related disorders, myeloproliferative disorders, aplastic anemia and bone marrow failure, stem cell transplantation, platelets and blood coagulation, bleeding disorders caused by vascular and platelet abnormalities, coagulation disorders, thrombosis and antithrombotic therapy, hematological changes in systemic disease, blood transfusion, and pregnancy and neonatal hematology. Each chapter includes full-color photographs and illustrations and concludes with a list of references. The book concludes with three appendices and a detailed subject index.

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Exercises for People With Hemophilia. Montréal, QC: World Federation of Hemophilia. 2006. 46 p.

This document provides a guide to exercise for people with hemophilia. The guide is intended for physical therapists with little experience working with people with bleeding disorders; other health care workers, including community rehabilitation workers; and people with hemophilia and their families. The author stresses that there is really no such thing as specific exercises for hemophilia. Exercise, like medicine, works best when there has been a complete assessment done by a trained professional, and specific exercises have been chosen that suit the individual's goals and abilities. The document includes four sections: how joints and muscles are affected by hemophilia, guidelines for exercise and hemophilia, suggested joint exercises, and suggested muscles exercises. Terms highlighted in the text are defined in a glossary at the end of the booklet. The author reminds readers of the importance of exercise for building healthy bones and strengthening the muscles that support joints, which is important in all people but vitally so in those with hemophilia. Most of the exercises are illustrated with simple line drawings demonstrating how to perform each movement. The document concludes with the contact information for the World Federation of Hemophilia, based in Montreal, Canada, and a bibliography. 37 figures. 1 table. 5 references.

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Guidelines for Dental Treatment of Patients With Inherited Bleeding Disorders. Montreal, Quebec: World Federation of Hemophilia. 2006. 9 p.

This monograph presents guidelines for the dental treatment of patients with inherited bleeding disorders, including hemophilia A and hemophilia B. The author notes that successful patient care protocols are the result of cooperation between hematologists and dentists. Most guidelines recommend the use of clotting factor replacement therapy before invasive oral surgery and the use of the inferior alveolar nerve block for restorative dental treatment. The use of local hemostatic techniques, such as suturing, and the use of oxidized cellulose has resulted in certain minor oral surgery procedures being done with minimal or no coagulation factor replacement. Topics in this document include prevention, dental treatment, periodontal treatment, removable prosthodontics, orthodontic treatment, restorative procedures, endodontics, anesthesia and pain management, surgery, postextraction hemorrhage, management of oral infections, and dental emergencies. 1 table. 35 references.

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