| Topic: | digestive diseases (dd) |
| Title: | Osteopenia. |
| Author: | Ghosh, S. |
| Source: | IN: Jewell, D.P., et al, eds. Challenges in Inflammatory Bowel Disease: Special Management Problems. Malden, MA: Blackwell Publishing Inc. pp. 340-359. |
| Availability: | Available from Blackwell Publishing Inc. Commerce Place, Malden, MA 02148. Phone: 1-800-216-2522. Email: orders@aidcvt.com. Website: http://www.blackwellpublishing.com. Price: $129.95. |
| Abstract: | Osteopenia, or low bone mineral density (BMD), is a recognized complication of inflammatory bowel disease (IBD). This chapter on osteopenia is from a textbook that addresses some of the challenges in the understanding of ulcerative colitis (UC) and Crohn’s disease (CD), collectively known as IBD. After a section on bone physiology, including the role of corticosteroids and physical activity on bone mass, the author discusses the effect of cytokines on bone metabolism, the measurement of BMD, biochemical markers of bone metabolism, the multifactorial pathogenesis of osteopenia in IBD, the differences between CD and UC and how those differences impact the development of osteopenia, osteopenia in children with IBD, and the management of osteopenia in IBD. The author concludes that osteopenia in IBD is multifactorial, with corticosteroid use being the most relevant determinant in UC and inflammatory activity being the most important determinant in CD. The rate of bone loss is variable and quite small in the majority of patients; universal treatment with agents that improve BMD may be unnecessary. All patients should be encouraged to take adequate calcium and vitamin D, exercise regularly, and stop smoking. 6 figures. 5 tables. 99 references. |
| Format: | Book Chapter |
| Language: | English. |
| Major Keywords: | Digestive System Diseases. Inflammatory Bowel Disease. Crohns Disease. Ulcerative Colitis. Osteopenia. Patient Care Management. |
| Minor Keywords: | Symptoms. Diagnostic Tests. Prognosis. Drug Therapy. Drug Effects. Bone Mineral Density. Prevention. Inflammation. Steroids. |
| Publication Number: | DDBK10513. |
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