| Topic: | Diabetes (DM) |
| Title: | Determinants of the Response to Regular Physical Activity: Genetic Versus Environmental Factors. |
| Author: | Rankinen, T.; Ravussin, E.; Bouchard, C. |
| Source: | In: Devlin, J.T. and Schneider, S.H., eds. Handbook of Exercise in Diabetes. Alexandria, VA: American Diabetes Association. 2002. p. 135-141. |
| Availability: | Available from American Diabetes Association (ADA). Order Fulfillment Department, P.O. Box 930850, Atlanta, GA 31193-0850. (800) 232-6733. Fax (770) 442-9742. Website: www.diabetes.org. PRICE: $69.95 plus shipping and handling. ISBN: 1580400191. |
| Abstract: | This chapter is from a book that provides a practical, comprehensive guide to diabetes and exercise for health care professionals involved in patient care. In this chapter, the authors consider genetic versus environmental factors as determinants of the response to regular physical activity. They note that there are marked interindividual differences in responsiveness to exercise training; in a group of subjects following an identical training program, some show no or only minor changes, whereas others show marked improvements in risk factor levels. Age, sex, and race do not seem to contribute to these individual differences. Pretraining phenotype levels are strong determinants of training responses for some phenotypes, such as blood pressure and heart rate, but have little effect on others, such as HDL (high density lipoprotein) cholesterol. Training response phenotypes are characterized by significant familial aggregation, suggesting the contribution of genetic factors and a shared environment. There is no evidence that some subjects are 'general non-responders.' Thus, effectiveness of a training program should be evaluated using several response indicators. Failure to normalize a patient's risk factor level with an exercise program is not necessarily only due to noncompliance. Even if a diabetic patient's blood glucose concentration does not decrease in response to training, it is likely that the exercise program has beneficial effects on other risk factors. 20 references. |
| Format: | Book Chapter |
| Language: | English. |
| Major Keywords: | Diabetes Mellitus. Exercise. Patient Care Management. Guidelines. Prevention. Complications. Risk Factors. Therapy. Metabolism. Physiology. |
| Minor Keywords: | Patient Compliance. Nutrition. Sports. Cardiovascular Diseases. Muscles. Patient Selection. Cardiovascular System. Rehabilitation. Blood Glucose. Blood Pressure. Genetics. Environmental Factors. |
| Publication Number: | DMBK10117 |
| Return to Search Results | |