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Sponsors and Collaborators: |
VU University Medical Center The Interuniversity Cardiology Institute of the Netherlands |
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Information provided by: | VU University Medical Center |
ClinicalTrials.gov Identifier: | NCT00269659 |
A left bundle branch block (LBBB) is related to abnormal cardiac conduction and mechanical asynchrony and is associated with hypertension and coronary artery disease. Improved evaluation of left ventricular (LV) mechanical asynchrony is needed, because of the increasing number of patients with a LBBB and heart failure. A variety of patterns of mechanical activation can be observed in LBBB patients.
Novel imaging modalities such as tissue Doppler imaging, real-time 3D echocardiography and cardiovascular magnetic resonance imaging provide information about regional and global LV function in healthy subjects, patients without a LBBB with heart failure, patients with a LBBB without heart failure, and patients with a LBBB with heart failure.
The investigators want to evaluate the different patient groups with the novel imaging modalities and they want to compare the novel imaging modalities with each other.
The investigators hypothesized that, between the groups, differences concerning regional and global LV function are measurable.
Each novel imaging technique has its own advantages and limitations but are comparable in measuring regional and global LV function.
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Serial Evaluation of Left Bundle Branch Block; Role of New Imaging Techniques. Three-Dimensional Echocardiography, Tissue Doppler Imaging, and Magnetic Resonance Imaging |
Estimated Enrollment: | 100 |
Study Start Date: | January 2004 |
Estimated Study Completion Date: | July 2007 |
Within a time period of 3 years we evaluate different groups of patients and measure regional and global cardiac function.
Therefore, we developed an echocardiography screening-protocol in which we use conventional 2D echocardiography and conventional Doppler echocardiography, extended with tissue Doppler imaging and real-time 3D echo acquisitions.
In a limited group of patients we perform a specially designed cardiovascular magnetic resonance imaging protocol which uses artificially induced grid-lines to evaluate regional and global cardiac function.
Patients are referred to our hospital because of evaluation of their LBBB and or heart failure. We ask them if they would like to undergo the echocardiography and the cardiovascular magnetic resonance imaging.
After a year we want to repeat the measurements in a small group of the patients to re-evaluate regional and global cardiac function.
All patients should have a sinus rhythm and adequate acoustic windows. Patients should not have contraindications for cardiovascular magnetic resonance imaging.
Ages Eligible for Study: | 18 Years to 85 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
For cardiovascular magnetic resonance imaging part:
Contact: Jeroen van Dijk, MD | +31 (0) 20 44 2244 | jeroen.vandijk@vumc.nl |
Contact: Otto Kamp, MD, PhD | +31 (0) 20 44 2244 | o.kamp@vumc.nl |
Netherlands | |
VU Medical Center | Recruiting |
Amsterdam, Netherlands, 1081 HV | |
Contact: Jeroen van Dijk, MD +31 (0) 20 444 2244 jeroen.vandijk@vumc.nl | |
Contact: Otto Kamp, MD, PhD +31 (0) 20 444 2244 o.kamp@vumc.nl | |
Principal Investigator: Jeroen van Dijk, MD | |
Sub-Investigator: Otto Kamp, MD, PhD |
Study Chair: | Otto Kamp, MD, PhD | VU University Medical Center |
Study ID Numbers: | VUMC 2003/147 |
Study First Received: | December 22, 2005 |
Last Updated: | June 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00269659 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
Left Bundle Branch Block Regional cardiac function Global cardiac function Mechanical asynchrony Echocardiography |
2D echocardiography Tissue Doppler Imaging Real-time 3D echocardiography Cardiovascular Magnetic Resonance Imaging-tagging |
Bundle-Branch Block Heart block progressive, familial Heart Failure |
Heart Diseases Heart Block Arrhythmias, Cardiac |
Pathologic Processes Cardiovascular Diseases |