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Sponsors and Collaborators: |
Samsung Medical Center H. Lundbeck A/S |
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Information provided by: | Samsung Medical Center |
ClinicalTrials.gov Identifier: | NCT00767871 |
Panic disorder is one of the most prevalent psychiatric disorders and recently abnormal fear network is known to be implicated in the pathophysiology of panic disorder. The fear network involves many brain regions such as amygdala, hippocampus, periaqueductal gray (PAG), locus coeruleus, parahippocampal gyrus, frontal cortex, and thalamus. Escitalopram, a highly selective serotonin reuptake inhibitor, is usually effective for panic dis order, but there is little information on how escitalopram affects the fear network.
The specific aim of this study is to test the following hypotheses using 18F-FDG positron emission tomography (PET)
Condition | Intervention | Phase |
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Panic Disorder |
Drug: Lexapro |
Phase IV |
Study Type: | Interventional |
Study Design: | Basic Science, Open Label, Single Group Assignment |
Official Title: | Changes of Cerebral Glucose Metabolism Associated With the Fear Network Activity Before and After 12 Weeks of Escitalpram Treatment in Panic Disorder |
Estimated Enrollment: | 20 |
Study Start Date: | March 2007 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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Escitalopram: Experimental
escitalopram (10-20mg) to panic patients
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Drug: Lexapro
12 week treatment with lexapro
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Ages Eligible for Study: | 20 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Eun-Ho Kang, M.D. | +82-3410-1384 | psychotx@naver.com |
Korea, Republic of | |
Samsung Medical Center | Recruiting |
Seoul, Korea, Republic of, 135-710 | |
Contact: Eun-Ho Kang, M.D. +82-3410-1384 psychotx@naver.com |
Principal Investigator: | Bum-Hee Yu, M.D., Ph.D. | Samsung Medical Center |
Responsible Party: | Department of Psychiatry, Samsung Medical Center ( Bum-Hee Yu, M.D. Ph.D. / Professor ) |
Study ID Numbers: | SMCIRB2007-01-024 |
Study First Received: | October 6, 2008 |
Last Updated: | October 6, 2008 |
ClinicalTrials.gov Identifier: | NCT00767871 |
Health Authority: | Korea: Food and Drug Administration |
Panic disorder PET Escitaopram |
Panic Disorder Anxiety Disorders Mental Disorders |
Dexetimide Citalopram Serotonin |
Neurotransmitter Uptake Inhibitors Neurotransmitter Agents Disease Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Psychotropic Drugs Serotonin Uptake Inhibitors |
Pharmacologic Actions Pathologic Processes Serotonin Agents Therapeutic Uses Antidepressive Agents, Second-Generation Central Nervous System Agents Antidepressive Agents |