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Sponsors and Collaborators: |
Centre Hospitalier Universitaire de Saint Etienne GRT : Groupe de Recherche sur la Thrombose |
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Information provided by: | Centre Hospitalier Universitaire de Saint Etienne |
ClinicalTrials.gov Identifier: | NCT00767182 |
Pregnancy complications called Placental Vascular Pathologies (PVP)are mainly responsible for perinatal mortality. In these cases, the placenta is smaller and often the centre of thrombotic lesions. The estimation of the placenta volume by 3D ultrasound coupled with growth factors and D-Dimers measures could improve the understanding of these pathologies to optimize their detection. Thus, the identification of predictive factors of the risk of occurrence or recurrence of PVP could allow us to propose a monitoring of patients at risk, to anticipate corticoids administration for the foetuses pulmonary maturation and perhaps later to adapt anti hypertensive and antithrombotic therapeutics.
Condition | Intervention |
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Placental Vascular Pathologies |
Other: blood sample |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Estimation of the Placental Volume by 3D Ultrasound at 12, 16 and 22 Weeks : Relation With Growth Factors and D-Dimers - Monocentric Prospective Cohort |
plasma and serum samples
Estimated Enrollment: | 40 |
Study Start Date: | August 2008 |
Estimated Study Completion Date: | May 2010 |
Estimated Primary Completion Date: | August 2009 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
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1
pregnancy women
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Other: blood sample
biological markers evaluated : D-Dimer, sEPCR
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Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
community sample
Inclusion Criteria:
Exclusion Criteria:
Contact: Céline Chauleur, MD | 0033477828611 | celine.chauleur@chu-st-etienne.fr |
France | |
Service de Gynécologie Obstétrique - CHU Saint-Etienne | Recruiting |
Saint-Etienne, France, 42055 | |
Contact: Céline Chauleur, MD 0033477828611 celine.chauleur@chu-st-etienne.fr | |
Principal Investigator: Marie Noelle Varlet, MD | |
Principal Investigator: Mireille Tronchet, MD | |
Principal Investigator: Emmanuelle Denis-Bellicard, MD |
Principal Investigator: | Céline CHAULEUR, MD | CHU de Saint-Etienne |
Responsible Party: | Service de Gynécologie Obstétrique CHU de Saint-Etienne ( Céline Chauleur ) |
Study ID Numbers: | 0808025 |
Study First Received: | October 3, 2008 |
Last Updated: | October 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00767182 |
Health Authority: | France: Direction Générale de la Santé |
preeclampsia eclampsia retroplacental hematoma |
vascular IUGR IUFD placental volume |
Hematoma Eclampsia Fibrin fragment D |
Pregnancy toxemia /hypertension Pre-Eclampsia Preeclampsia |