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Sponsors and Collaborators: |
Centre Hospitalier Universitaire de Saint Etienne Ministry of Health, France |
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Information provided by: | Centre Hospitalier Universitaire de Saint Etienne |
ClinicalTrials.gov Identifier: | NCT00766584 |
The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity.
Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population. It is even associated with sleep apnea/hypopnea.
Condition | Intervention |
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Healthy |
Other: Sleep apnea/hypopnea detection |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea in a Prospective Cohort of Subjects Aged 67 Years |
Serum
Enrollment: | 852 |
Study Start Date: | January 2003 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
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PROOF cohort
This cohort is the same than the PROOF study (NCT00759304). Subjects were recruited amongst the inhabitants of the city of Saint-Etienne, France, and were eligible if aged 65 at the inclusion date in the PROOF study
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Other: Sleep apnea/hypopnea detection
Simultaneous 24-hour ambulatory electrocardiogram and polygraphic recordings performed at home during a night.
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The main goal of this SYNAPSE study is to evaluate, on a selected prospective cohort of subjects aged 67 years upon study entry, the incidence of sleep apnea/hypopnea and the prognostic values of ANS activity levels measured at preset times and of cardiovascular or cerebrovascular events.
Ages Eligible for Study: | 67 Years to 68 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Subjects were recruited amongst the inhabitants of the city of Saint-Etienne, France, and were eligible if aged 65 at the inclusion date in the PROOF study
Inclusion Criteria:
Exclusion Criteria:
France | |
Centre Hospitalier de Saint-Etienne | |
Saint-Etienne, France, 42055 |
Principal Investigator: | Jean-Claude BARTHELEMY, MD PhD | CHU de Saint-Etienne |
Responsible Party: | CHU de Saint-Etienne ( Françoise LORCA ) |
Study ID Numbers: | 0201085, DGS 2003/0069 |
Study First Received: | October 3, 2008 |
Last Updated: | October 6, 2008 |
ClinicalTrials.gov Identifier: | NCT00766584 |
Health Authority: | France: French Data Protection Authority; France: Ministry of Health |
Aging Autonomic nervous system stroke |
Myocardiac infarction Prospective cohort Sleep apnea/hypopnea |
Sleep Apnea Syndromes Respiratory Tract Diseases Cerebral Infarction Apnea Respiration Disorders Stroke |
Dyssomnias Sleep Disorders Healthy Infarction Sleep Disorders, Intrinsic |
Nervous System Diseases |