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Sponsors and Collaborators: |
University of Mississippi Medical Center Office of Minority Health Mississippi Institute for Improvement of Geographic Minority Health |
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Information provided by: | University of Mississippi Medical Center |
ClinicalTrials.gov Identifier: | NCT00653809 |
The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.
Condition |
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Preeclampsia |
Study Type: | Observational |
Study Design: | Case Control, Cross-Sectional |
Official Title: | Elucidating the Role of Nitric Oxide and Endothelin-1 Activation in Endothelial Cells co-Cultured With Placental Explants From African-American and Caucasian High Risk Pregnancies |
Placental Tissue
Estimated Enrollment: | 45 |
Study Start Date: | June 2007 |
Estimated Study Completion Date: | March 2009 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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A, 1, I
Caucasian women without preeclampsia or PIH, delivering their first child
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A, 1, II
Caucasian women with preeclampsia or PIH, delivering their first child
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A, 2, I
African-american women without preeclampsia or PIH, delivering their first child
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A, 2, II
African-American women with preeclampsia or PIH, delivering their first child
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B, 1, I
Caucasian women without preeclampsia or PIH, delivering at least their second child
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B, 1, II
Caucasian women with preeclampsia or PIH, delivering at least their second child
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B, 2, I
African-american women without preeclampsia or PIH, delivering at least their second child
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B, 2, II
African-american women with preeclampsia or PIH, delivering at least their second child
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Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Women delivering babies at the University of MS Medical Center
Inclusion Criteria:
Exclusion Criteria:
Contact: Kedra L Wallace, MS | 601-984-5311 | kwallace2@pharmacology.umsmed.edu |
Contact: William A Bennett, PhD | 601-984-5301 | wbennett@ob-gyn.umsmed.edu |
United States, Mississippi | |
University of MS Medical Center | Recruiting |
Jackson, Mississippi, United States, 39216 | |
Contact: Kedra L Wallace, MS 601-984-5311 kwallace2@pharmacology.umsmed.edu | |
Contact: William A Bennett, PhD 601-984-5301 wbennett@ob-gyn.umsmed.edu | |
Principal Investigator: Kedra L Wallace, MS |
Principal Investigator: | Kedra L Wallace, MS | Obstetrics & Gynecology |
Responsible Party: | University of MS Medical Center ( Kedra Walllace/Researcher IV ) |
Study ID Numbers: | 2007-0065-MIGMH |
Study First Received: | April 1, 2008 |
Last Updated: | November 12, 2008 |
ClinicalTrials.gov Identifier: | NCT00653809 |
Health Authority: | United States: Institutional Review Board |
Nitric Oxide Hypertension, Pregnancy-Induced Pregnancy Complications Eclampsia |
Pregnancy toxemia /hypertension Pre-Eclampsia Preeclampsia Hypertension |
Respiratory System Agents Vasodilator Agents Neurotransmitter Agents Antioxidants Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Anti-Asthmatic Agents Cardiovascular Agents |
Protective Agents Pharmacologic Actions Autonomic Agents Therapeutic Uses Free Radical Scavengers Endothelium-Dependent Relaxing Factors Peripheral Nervous System Agents Bronchodilator Agents |