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Sponsored by: |
Royal Marsden NHS Foundation Trust |
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Information provided by: | Royal Marsden NHS Foundation Trust |
ClinicalTrials.gov Identifier: | NCT00301314 |
The majority of patients with Hodgkin Lymphoma (HL)are cured with radiation therapy and/or combination chemotherapy. However, patients who relapse after attaining a complete remission with chemotherapy and those with primary refractory disease have a poor outcome with conventional chemotherapy regimens. Treatment results with standard−dose second−line regimens produce low complete remission rates and minimal survival benefit. Single institution studies have shown better outcome after autologous stem cell transplant in this group of patients when compared to historical controls receiving conventional treatment. In this retrospectve review, we aim to analyse outcome and determine independent prognostic factors which would correlate with the long−term outcome of patiensts with HL who received an autologous stem cell transplant in the past at the Royal Marsden Hospital Eligible patients (those on current−follow−up) identified from the transplant database will be eligible for the study.
Accrual of eligible patients currently under follow−up will be performed in clinic at the time of next appointment. All patients accrued will give informed consent to participate in the study for retrospective case note review, after discussion with a study investigator and after receiving a study information sheet. The results of the analysis will be published in a peer−reviewed medical journal.
Condition | Intervention |
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Hodgkin Lymphoma |
Procedure: Autologous stem cell transplant |
Study Type: | Observational |
Study Design: | Longitudinal, Defined Population, Retrospective Study |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Inclusion Criteria:
Exclusion Criteria:
Contact: Bhawna Sirohi, MBBS, MD | 0044 208 661 3115 | bhawna.sirohi@rmh.nhs.uk |
United Kingdom, Surrey | |
Royal Marsden NHS trust | Recruiting |
Sutton, Surrey, United Kingdom, SM2 5PT | |
Contact: Bhawna Sirohi, MBBS, MD 0044 208 661 3115 bhawna.sirohi@rmh.nhs.uk | |
Contact: Jacqui Oates 00442086613279 jacqui.oates@rmh.nhs.uk | |
Sub-Investigator: Bhawna Sirohi, MBBs, MD |
Principal Investigator: | David Cunningham, FRCP | Royal Marsden NHS Foundation Trust |
Study ID Numbers: | 2655 |
Study First Received: | March 9, 2006 |
Last Updated: | October 12, 2006 |
ClinicalTrials.gov Identifier: | NCT00301314 |
Health Authority: | United Kingdom: National Health Service |
Lymphatic Diseases Hodgkin's disease Immunoproliferative Disorders Hodgkin lymphoma, adult |
Lymphoproliferative Disorders Hodgkin Disease Lymphoma |
Neoplasms Neoplasms by Histologic Type Immune System Diseases |