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Sponsors and Collaborators: |
Zentrum für Integrative Psychiatrie Stanley Medical Research Institute |
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Information provided by: | Zentrum für Integrative Psychiatrie |
ClinicalTrials.gov Identifier: | NCT00300404 |
We investigate whether the add-on specific antitoxoplasmatic medication has positive effects in individuals with schizophrenia or major depression seropositive for Toxoplasma gondii (TG) infection. As TG modulates neurotransmitter metabolism affecting serotonin and dopamine we hypothesize that this chronic persistent infection might play a role for depressive and psychotic symptomatology. Therefore, on the basis of an ex juvantibus approach, specific anti TG medication might further improve psychiatric symptomatology in affected patients. This is investigated in a double-blind, placebo-controlled, randomized treatment trial.
Condition | Intervention | Phase |
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Schizophrenia Major Depression |
Drug: daraprim Drug: pyrimethamine Drug: folinic acid |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Effect of Add-on Anti-Toxoplasmosis Treatment on Parameters Defining Toxoplasma Gondii Infection and on Psychopathology in Patients With Schizophrenia or Major Depression Serologically Positive for Toxoplasma Gondii - Phase 3 Study |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | TOXO-KI-TT, SMRI grant # 01T-404 |
Study First Received: | March 7, 2006 |
Last Updated: | May 19, 2006 |
ClinicalTrials.gov Identifier: | NCT00300404 |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
Schizophrenia Psychosis Depression Affective Disorder |
Pyrimethamine Protozoan Infections Depression Leucovorin Depressive Disorder, Major Depressive Disorder Toxoplasmosis Behavioral Symptoms |
Folic Acid Schizophrenia Mental Disorders Mood Disorders Psychotic Disorders Parasitic Diseases Schizophrenia and Disorders with Psychotic Features |
Anti-Infective Agents Antiprotozoal Agents Vitamin B Complex Molecular Mechanisms of Pharmacological Action Coccidiosis Growth Substances Physiological Effects of Drugs Enzyme Inhibitors |
Folic Acid Antagonists Pharmacologic Actions Antimalarials Antiparasitic Agents Vitamins Therapeutic Uses Micronutrients |