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Effects of Exercise Training on Left Ventricular Function in Type 2 Diabetic Patients Post Coronary Artery Bypass Graft
This study has been suspended.
Sponsored by: National Taiwan University Hospital
Information provided by: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00172536
  Purpose

The purpose of this study is to investigate the changes of cardiorespiratory fitness and left ventricular function in type 2 diabetes after uncomplicated coronary artery bypass graft (CABG) surgery.

We hypothesize that exercise capacity, left ventricular diastolic function, and biochemical data improves after 12-wk exercise training in patients with type 2 diabetes underwent CABG.


Condition Intervention
Diabetes Mellitus, Non-Insulin-Dependent
Coronary Arteriosclerosis
Coronary Artery Bypass Grafting,
Exercise
Doppler Echocardiography.
Behavioral: structural aerobic exercise training

MedlinePlus related topics: Coronary Artery Bypass Surgery Diabetes Exercise and Physical Fitness
U.S. FDA Resources
Study Type: Interventional
Study Design: Educational/Counseling/Training, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study

Further study details as provided by National Taiwan University Hospital:

Study Start Date: October 2004
Estimated Study Completion Date: May 2005
Detailed Description:

Patients with type 2 diabetes mellitus have higher incidence of coronary artery disease or left ventricular dysfunction, particularly diastolic dysfunction. Coronary artery bypass surgery is known to decrease the mortality rate in diabetes. Further exercise training can improve their cardiorespiratory fitness and the control of risk factors in these patients. However, the extent of improvement and the mechanism, especially the changes in left ventricular function, in diabetes after exercise training have not been fully explored.

Subjects will be assigned to the intervention or control group by randomization. Subjects in the intervention group will receive 60% VO2 max moderate aerobic exercise training, twice per week under supervision and three times per week at home, for 12 weeks. All subjects receive left ventricular function test by echocardiography and impedance cardiography, graded maximal exercise test, and biochemical analyses of sugar and lipid before and after 12 weeks. Their dietary intake and physical activity will be inquired every 4 weeks by questionnaires.

  Eligibility

Ages Eligible for Study:   40 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • well-controlled diabetes
  • no history of myocardial infarction
  • stable post CABG for at least 3 months

Exclusion Criteria:

  • heart failure
  • valvular disease
  • abnormal kidney or liver function
  • cerebrovascular disease
  • primary pulmonary disease
  • other systemic or acute illness that may impede the testing or training
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00172536

Locations
Taiwan
National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Director: Ying-Tai Wu, Doctor National Taiwan University Hospital
  More Information

Study ID Numbers: 9361701147
Study First Received: September 12, 2005
Last Updated: November 23, 2005
ClinicalTrials.gov Identifier: NCT00172536  
Health Authority: Taiwan: Department of Health

Study placed in the following topic categories:
Arterial Occlusive Diseases
Heart Diseases
Metabolic Diseases
Myocardial Ischemia
Diabetes Mellitus
Vascular Diseases
Endocrine System Diseases
Arteriosclerosis
Ischemia
Coronary Disease
Diabetes Mellitus, Type 2
Endocrinopathy
Metabolic disorder
Glucose Metabolism Disorders
Coronary Artery Disease

Additional relevant MeSH terms:
Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009