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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00172471 |
Sleep disorders are common in patients with end-stage renal disease on both hemodialysis and peritoneal dialysis and are associated with significant medical, psychological and social disturbances. Numerous factors have been suggested as contributing to or associated with the high prevalence of sleep disturbance in this population.
Increasing evidence suggests that cytokines are involved in the regulation of sleep and wakefulness and that the communication between the sleep and the immune system is bi-directional. Blood-dialyzer or peritoneum-dialysate interaction during dialysis therapy has the potential to activate mononuclear cells leading to production of inflammatory cytokines. These cytokines are believed to play a significant role in dialysis-associated morbidity and mortality. Nevertheless, a cytokine overproduction may alter sleep pattern in chronic dialyzed patients, thus explaining the presence of sleep disorders in these patients. In the other way, sleep loss may have effects on immune process and secretion of cytokines in chronic dialyzed patients. The purpose of this study was to examine the relationship between quality of sleep and serum cytokine levels in hemodialysis and peritoneal dialysis patients.
Condition |
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Renal Failure Sleep Disorder Hemodialysis Peritoneal Dialysis |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Defined Population, Retrospective/Prospective Study |
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Taiwan | |
Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital | |
Taipei, Taiwan, 100 |
Principal Investigator: | Jenq-Wen Huang, MD | Department of Internal Medicine, National Taiwan University Hospital |
Study ID Numbers: | 9361700775 |
Study First Received: | September 12, 2005 |
Last Updated: | December 20, 2005 |
ClinicalTrials.gov Identifier: | NCT00172471 |
Health Authority: | Taiwan: Department of Health |
Signs and Symptoms Renal Insufficiency Urologic Diseases Mental Disorders |
Neurologic Manifestations Sleep Disorders Kidney Diseases Kidney Failure |
Pathologic Processes Disease Nervous System Diseases |