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National Cancer Institute - U.S. National Institutes of Health - www.cancer.gov

Clinical Trials by Cancer Site

Kidney Cancer

Kidney cancer is the result of cancer cell developing in the tissues of the kidney. There are several types of kidney cancer, including renal cell carcinoma, renal pelvis carcinoma, and Wilms' tumor, which is the type of kidney cancer that develops in children under 5 years of age. It is a disease that most often develops in adults over 40 years of age; males are more likely than females to be diagnosed with kidney cancer.

It is estimated that in 2008 there will be 54,390 new cases of kidney cancer and 13,010 kidney-cancer-related deaths in the United States. Several widely accepted risk factors include gender, smoking, obesity, high blood pressure, long-term dialysis, Von Hippel-Lindau syndrome, and occupational hazards.

Treatment options for kidney cancer may vary depending on the stage of the disease, the patient's age, whether the cancer is newly diagnosed or recurrent, and other medical conditions, and should be discussed with the patient's physician.

Kidney Cancer Clinical Trials

The Center for Cancer Research (CCR), NCI's largest division doing research on campus, conducts kidney cancer clinical trials at the NIH Clinical Center in Bethesda, Md. NCI accepts referrals to kidney cancer clinical trials conducted in Bethesda, Md., through its Clinical Trials Referral Office (formerly the Clinical Studies Support Center) at 1-888-NCI-1937 (1-888-624-1937).

NCI is currently conducting the following trials for patients with kidney cancer. Click on the trials below for additional details, including a summary of eligibility criteria, treatment plan, and information on how to contact the principal investigators and their staff directly.


  
Trial and Protocol Number
Kidney (Renal Cell) Cancer
Phase II
A Phase II Study of ZD6474 (Vandetanib) in Subjects With Advanced Clear Cell Renal Carcinoma
NCI-08-C-0039

Principal Investigator:Referral Contact:
W. Marston LinehanDavid Draper
301-496-6353301-435-5614
draperd@mail.nih.gov
A Phase II Study of the c-Met RTK Inhibitor GSK 1363089 (Formerly XL880) in Subjects With Papillary Renal-Cell Carcinoma (PRC)
NCI-07-C-0121

Principal Investigator:Referral Contact:
Ramaprasad SrinivasanMartha Ninos
301-496-6353301-435-8897
mninos@mail.nih.gov
A Phase II Clinical Trial of BMS-247550 (NSC 710428), an Epothilone B Analog, in Renal Cell Carcinoma
NCI-02-C-0130

Principal Investigator:Referral Contact:
Antonio Tito FojoMaureen Edgerly
301-402-1357301-435-5604
edgerlym@mail.nih.gov
Phase I/II
Low Intensity Allogeneic Hematopoietic Stem Cell Transplantation Therapy of Metastatic Renal Cell Carcinoma Using Early and Multiple Donor Lymphocyte Infusions Consisting of Sirolimus-Generated Donor Th2 Cells
NCI-08-C-0088

Principal Investigator:Referral Contact:
Daniel FowlerMike Krumlauf
301-435-8641301-594-2056
krumlaum@mail.nih.gov


  
Trial and Protocol Number
Leiomyomatosis
No Phase
Hereditary Leiomyomatosis Renal Cell Cancer (HLRCC): Identification of the Disease Gene, and Characterization of the Predisposition to Renal Cancer
NCI-03-C-0066

Principal Investigator:Referral Contact:
W. Marston Linehan
301-496-6353



  
Trial and Protocol Number
Melanoma, Skin
Phase I
A Phase I Study of Subcutaneous "CYT 107" (Interleukin-7) in Refractory Metastatic Melanoma or Renal Cell Carcinoma
NCI-07-C-0114

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov


  
Trial and Protocol Number
Solid Tumor (Adult)
Phase II
Phase II Study of Metastatic Cancer That Overexpresses p53 Using Lymphodepleting Conditioning Followed by Infusion of Anti-p53 TCR-Gene Engineered Lymphocytes and Dendritic Cell Vaccination
NCI-08-C-0155

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase II Study of Metastatic Cancer That Expresses NY-ESO-1 Using Lymphodepleting Conditioning Followed by Infusion of Anti-NY ESO-1 TCR-Gene Engineered Lymphocytes
NCI-08-C-0121

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase I
A Phase I Investigation of IL-12/Pulse IL-2 in Adults With Advanced Solid Tumors
NCI-00-C-0121

Principal Investigator:Referral Contact:
John E. JanikGuinevere Chun
301-402-2913301-451-7868
gchun@mail.nih.gov


  
Trial and Protocol Number
Von Hippel-Lindau
Phase II
A Phase II Study of ZD6474 (Vandetanib) in Patients With Von Hippel Lindau Disease and Renal Tumors
NCI-08-C-0020

Principal Investigator:Referral Contact:
W. Marston LinehanSarah Fowler
301-496-6353301-435-6255
fowlers@mail.nih.gov
A Phase II Study of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Von Hippel Lindau Disease and Renal Tumors
NCI-04-C-0238

Principal Investigator:Referral Contact:
W. Marston Linehan
301-496-6353

No Phase
Clinical Manifestations and Molecular Bases of Heritable Urologic Malignant Disorders
NCI-89-C-0086

Principal Investigator:Referral Contact:
W. Marston Linehan
301-496-6353



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