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Sponsored by: |
National University Hospital, Singapore |
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Information provided by: | National University Hospital, Singapore |
ClinicalTrials.gov Identifier: | NCT00622882 |
The primary objective is to determine if early infectious disease (ID) consultation (defined as within 48 hours of a positive blood culture) will reduce mortality rates from Staphylococcus aureus bacteremia (SAB). This study will also determine if such consultations could reduce the duration of hospitalisation, recurrence and financial costs in patients with this infection.
Condition | Intervention |
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Staphylococcus Aureus Bacteremia |
Other: infectious disease specialist consultation |
Study Type: | Interventional |
Study Design: | Health Services Research, Randomized, Open Label, Parallel Assignment, Efficacy Study |
Official Title: | Early Infectious Disease Consultation for Better Outcomes From Staphylococcus Aureus Bacteremia |
Estimated Enrollment: | 200 |
Study Start Date: | October 2007 |
Estimated Study Completion Date: | August 2008 |
Estimated Primary Completion Date: | August 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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ID: Active Comparator
Patients receiving an early Infectious disease consultation ( within first 48 hours of a positive blood culture)
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Other: infectious disease specialist consultation
Randomised trial to determine the utility of an early Infectious disease Consultation in Staphylococcus aureus bacteremic patients ( in the first 48 hours of a positive blood culture)
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NO ID: No Intervention
Includes those patients who do not receive an Infectious disease consultation in the first 48 hours
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Bacteremia is a serious manifestation of Staphylococcus aureus infection with an attributable mortality as high as 25% in MRSA bacteremia. More than a third of patients end up with complications such as endocarditis, osteomyelitis or pneumonia.
Overall the outcome of patients with respect to mortality or recurrence is better in patients who have an eradicable focus and have received an appropriate antibiotic dose and duration. Also complicated bacteremia is more common in patients with
Based on this evidence, an ID consultation could improve the outcomes of patients with SAB by
Ages Eligible for Study: | 1 Month and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Paul A Tambyah, MD | (65)67724375 | mdcpat@nus.edu.sg |
Singapore | |
National University Hospital | Recruiting |
Singapore, Singapore, 11974 | |
Contact: Paul A Tambyah, Dip ABIM (65)67724375 mdcpat@nus.edu.sg | |
Principal Investigator: Paul A Tambyah, Dip ABIM |
Principal Investigator: | Paul A Tambyah, MD | National University, Singapore |
Responsible Party: | National University Hospital ( Paul Tambyah/Associate Professor ) |
Study ID Numbers: | DSRB-B/06/274, DSRB-B/06/274 |
Study First Received: | February 13, 2008 |
Last Updated: | May 8, 2008 |
ClinicalTrials.gov Identifier: | NCT00622882 |
Health Authority: | Singapore: Health Sciences Authority |
Staphylococcus aureus Bacteremia Outcome |
Mortality Recurrence Infectious Diseases specialists |
Systemic Inflammatory Response Syndrome Bacterial Infections Staphylococcal Infections Gram-Positive Bacterial Infections |
Sepsis Bacteremia Recurrence Inflammation |
Communicable Diseases Pathologic Processes Infection |