Brain Tumor (Childhood)
An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
NCI-06-C-0219
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Investigator(s): |
Katherine E. Warren, M.D.
Principal Investigator
Phone: 301-496-4256
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Kevin Camphausen, M.D.
Protocol Chair
Phone: 301-496-5457
camphauk@mail.nih.gov
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Robyn Bent, R.N.
Research Nurse
Phone: 301-496-8009
rbent@mail.nih.gov
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Pediatric Oncology
Phone: 1-877-624-4878
(Toll free)
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Primary Eligibility:
- Patients must have a primary CNS tumor for which radiation therapy is recommended
- Patients must be ≤ 21 years of age
- Patients who have undergone prior surgery or who have received chemotherapy are eligible
- Patients will be eligible regardless of performance score
- Patients who are unable to undergo an MRI are ineligible
- Patients who have received prior radiation are ineligible
Treatment Plan:
- This study includes the analysis of blood, urine and CSF (if available) to measure biological markers involved with angiogenesis, blood/brain barrier integrity and neurotoxicity
- Comprehensive MR imaging techniques and neuropsychological testing will be conducted in an effort to correlate changes with biomarker measurements
- Patients on this protocol will receive radiation therapy on a separate protocol as prescribed by the radiation oncologist
Additional Information:
- This trial will be conducted at the NIH Clinical Center in Bethesda, MD. It is open to patients who meet the eligibility requirements, regardless of where they live in the United States.
- There is no charge for medical care received at NIH Clinical Center.
- PDQ (Physicians Data Query) - provides additional details about this study for health care providers.
Reviewed: 11/17/08
Updated: 12/12/06
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