Inclusion Criteria:

• Patients must have uveal melanoma for which enucleation is indicated, usually lesions greater than 8 mm in diameter and greater than 2 mm in thickness.
• Patients should have no evidence of metastatic disease as determined by history, physical examination, and appropriate liver injury enzymes.
• Patients should have received no prior interferon.
• Age >18 years.

Because of limited data on the use of pegylated interferon in patients <18 years of age and uncertainties about possible differences in NK response, children are excluded from this study. Since ocular melanoma is rare in children this is not expected to be an issue.

• Life expectancy of greater than 3 months
• ECOG performance status of 0- 2 (Karnofsky 60% or better; see Appendix II).
• Patients must have normal organ and marrow function as defined below:

• Hgb >/= 12.5 g/dl or hematocrit >/= 38%

  • Leukocytes >3,000/mcL
  • Absolute neutrophil count >1,500/mcL
  • Platelets>100,000/mcL
  • Total bilirubin within normal institutional limits unless patient has Gilbert's syndrome
  • AST(SGOT)/ALT(SGPT) within normal institutional limits. Patients with elevated levels of either of these enzymes may be accepted if the elevations are less than or equal to 2x the institutional upper limit of normal and patient has a normal liver on CT or MRI.
  • Creatinine within normal institutional limits OR Creatinine clearance >60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal
• Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for one year after the study drug is given. Should a woman become pregnant or suspect she is pregnant while participating in this study,she should inform her treating physician immediately.
• Ability to understand and the willingness to sign a written informed consent document.
• Both men and women and members of all races and ethnic groups are eligible for this trial.

Exclusion Criteria:

• Patients who have had agents known to be immunosuppressive (e.g, glucocorticoids) within the 4 weeks prior to planned receipt of study drug.
• Patients receiving any other investigational agents.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Pregnant women are excluded from this study because interferon alpha has the potential for teratogenic effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with interferon, breastfeeding should be discontinued if the mother is treated with this agent.
• HIV-positive patients are ineligible because of the known immunosuppression associated with this disease.
• Patients with history of other malignancies are eligible provided that they are clinically free of metastases at the time of the study.
• Patients who have donated blood in the 56 days prior to the 500cc blood draw in this study are not eligible.