Cancer Control Research
5R01CA063700-03
Carstea, Eugene D.
IDENTIFICATION OF LUNG CANCER SUSCEPTIBILITY GENES
AbstractDESCRIPTION: (Adapted from investigator's abstract) The long-term goal of
this project is to identify tumor susceptibility genes involved in lung
cancer development. There are six specific aims: 1) to generate pedigrees
for lung cancer susceptible families; 2) to obtain normal and tumor tissue
samples from as many family members as possible; 3) to genotype DNA from
family members with appropriate markers; 4) to perform linkage analyses to
identify potential loci involved in lung cancer susceptibility; 5) to
genotype the entire genome with equally spaced microsatellite markers and
perform linkage analysis with these data; and, 6.) if putative loci are
localized, to refine the linkage map of the candidate loci.
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