Relationship of Genes and Life Events to Blood Pressure

This study has been completed.

Sponsored by:	Sunnybrook Health Sciences Centre
Information provided by:	Sunnybrook Health Sciences Centre
ClinicalTrials.gov Identifier:	NCT00327431

Purpose

Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Condition	Intervention
Hypertension Psychosocial Factors	Genetic: Cheek swab samples for DNA

MedlinePlus related topics: High Blood Pressure

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective

Further study details as provided by Sunnybrook Health Sciences Centre:

Estimated Enrollment:	120
Study Start Date:	November 2006
Study Completion Date:	December 2007

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion Criteria:

Withdrawal of consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00327431

Locations

Canada, Ontario
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5

Sponsors and Collaborators

Sunnybrook Health Sciences Centre

Investigators

Study Chair:	Brian Baker, MB, ChB	University of Toronto
Study Chair:	Sheldon Tobe, MD	Sunnybrook Health Sciences Centre

More Information

Publications:

Tobe SW, Kiss A, Szalai JP, Perkins N, Tsigoulis M, Baker B. Impact of job and marital strain on ambulatory blood pressure results from the double exposure study. Am J Hypertens. 2005 Aug;18(8):1046-51.

Study ID Numbers:	1000009109
Study First Received:	May 17, 2006
Last Updated:	May 21, 2008
ClinicalTrials.gov Identifier:	NCT00327431
Health Authority:	Canada: Ethics Review Committee

Keywords provided by Sunnybrook Health Sciences Centre:

Hypertension
Blood Pressure
Psychosocial Factors

Study placed in the following topic categories:

Vascular Diseases
Hypertension

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 14, 2009