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Sponsored by: |
Rockefeller University |
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Information provided by: | Rockefeller University |
ClinicalTrials.gov Identifier: | NCT00327236 |
The investigators believe that T cells, cells that are a part of the immune system, are what are causing the neurological problems while also attacking tumor cells. This protocol studies the clinical status of patients with paraneoplastic neurological disorder (PND) as well as their blood to understand the relationship between their neurological disease, their cancer, and their immune system.
Condition |
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Paraneoplastic Syndromes |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Killer T Cell Activity in the Paraneoplastic Neurologic Syndromes |
Estimated Enrollment: | 9 |
Patients with paraneoplastic neurological disorders (PNDs) provide a unique model for studying tumor immunity and neuronal autoimmunity. We hypothesize that T lymphocyte autoimmune dysfunction is involved in the pathogenesis of the paraneoplastic neurological syndromes, and that killer T cells are involved in the targeting and successful killing of tumor cells in these cancer patients. Furthermore, we postulate that this activity may provide a model for autoimmune brain disease. We will assess the immune responses in PND patients, correlate these with the clinical data (time course of disease, symptoms and signs, disability), and collect and archive clinical data, serum and cells from PND patients for current and future studies into the basic immune system phenomenon present in PND patients.
Ages Eligible for Study: | 16 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Noreen Buckley, NP | 212-327-7454 |
United States, New York | |
Rockefeller University Hospital | Recruiting |
New York, New York, United States, 10021 | |
Contact: Noreen Buckley, NP 212-327-7454 nbuckley@rockefeller.edu | |
Principal Investigator: Robert Darnell, MD, PHD |
Principal Investigator: | Robert Darnell, MD, PHD | Rockefeller University |
Study ID Numbers: | RDA-0148 |
Study First Received: | May 17, 2006 |
Last Updated: | October 15, 2007 |
ClinicalTrials.gov Identifier: | NCT00327236 |
Health Authority: | United States: Institutional Review Board |
Paraneoplastic Neurologic Syndromes |
Paraneoplastic Syndromes |
Neoplasms Pathologic Processes Disease Syndrome |