2003 NICHD ANNUAL REPORT




Board of Scientific Counselors Scientific Director’s Preface Workshops Bone and Extracellular Matrix Branch Connective Tissue Disorders: Joan Marini Cell Biology and Metabolism Branch Protein Sorting in the Endosomal-Lysosomal System: Juan Bonifacino Regulation of Secretory and Membrane Protein Biogenesis: Ramanujan Hegde Regulation of Membrane Dynamics and Protein Transport by the Sec7 Domain Guanine Nucleotide Exchange Factors: Catherine Jackson Cell Cycle Regulation during Oogenesis: Mary Lilly Dynamics of Secretory Membrane Trafficking, Sorting and Compartmentalization: Jennifer Lippincott-Schwartz Regulation of Intracellular Iron Metabolism:Tracey Rouault Microbial Responses to Oxidative Stress and Noncoding RNAs: Gisela Storz Developmental Endocrinology Branch Neuroendocrinology of Stress: Greti Aguilera Regulation of Skeletal Growth: Jeffrey Baron Genes or Hormones? Gender-Specific Differences in Disease Susceptibility: Carolyn Bondy The Menstrual Cycle and Human Reproduction: Lawrence Nelson Molecular Genetics of Adrenocortical Tumors and Related Disorders: Constantine Stratakis Physiology, Psychology and Genetics of Obesity: Jack Yanovski Endocrinology and Reproduction Research Branch Phosphoinositide-Calcium Signaling in Cell Regulation: Tamás Balla Peptide Hormone Receptors and Signal Transduction: Kevin Catt Structure and Function of Peptide and Protein Hormones: Hao-Chia Chen Gonadal Receptors and Mechanism of Action of Peptide Hormones in Steroidogenic Cells: Maria Dufau Signal Transduction In Synaptic Transmission and Plasticity: Kuo-Ping Huang Calcium Signalling and Calcium-Controlled Cellular Functions: Stanko Stojilkovic The Biotransformation of Endobiotics by Sulfonation: Charles Strott Heritable Disorders Branch Molecular Genetics of Heritable Human Disorders: Janice Chou Heritable Autoimmune and Neurodegenerative Disorders: Anil Mukherjee Molecular Biology, Regulation, and Biochemistry of UDP-Glucuronosyltransferase Isozymes: Ida Owens Dysmorphic Syndromes and Birth Defects: Forbes Porter Laboratory of Cellular and Molecular Biophysics Protein-Mediated Remodeling of Membrane Lipid Bilayers: Leonid Chernomordik Advances in the Methodology of Electrophoretic Separation: Andreas Chrambach Microbial Pathogens in Human Lymphoid Tissue: Leonid Margolis Applications of Mass Spectrometry to Biophysics, Biochemistry and Medicine: Alfred Yergey Membrane Remodeling During Pathogenesis and the Mechanism of Exocytosis: Joshua Zimmerberg Laboratory of Cellular and Molecular Neurophysiology Structure and Function of Glutamate Receptors: Mark Mayer Laboratory of Cellular and Synaptic Neurophysiology Potassium Channels and Dendritic Function in Hippocampal Pyramidal Neurons: Dax Hoffman Neurotrophic Regulation of Synapse Development and Plasticity: Bai Lu Hippocampal Interneurons and their Role in Controlling Excitability: Chris Mcbain Olfactory Coding and Decoding by Ensembles of Neurons: Mark Stopfer Laboratory of Clinical Genomics Clinical Genomics: Owen Rennert Bridging the Gap between Monogenic Traits and Complex Inherited Disorders of Childhood: Stephen Kaler Laboratory of Comparative Ethology Child and Family Development in the First Two Decades of Life: Marc Bornstein Child Development in Context: Michael Lamb Mechanisms Regulating Auditory Communication and Social Behavior in Primates: John Newman Genetic and Environmental Determinants of Primate Biobehavioural Development: Stephen Suomi Laboratory of Developmental and Molecular Immunity Vaccines Against Human Pathogenic Bacteria: John Robbins Human Immune Response to Polysaccharide-Protein Conjugate Vaccines: Rachel Schneerson Laboratory of Developmental Neurobiology Developmental Regulation of Neuronal and Muscle Plasticity: Andres Buonanno Regulation of Pineal Function: The Pineal Gland: David Klein Secretory Protein Trafficking and Granule Biogenesis in Neuroendocrine Cells: Peng Loh Tetanus and Botulinum Neurotoxins and Neuronal Cell Biology: Elaine Neale Mechanisms of Neurodevelopment in Health and Disease: Phillip Nelson Laboratory of Gene Regulation and Development Mitotic Regulation in Higher Eukaryotes by Ran and SUMO-1: Mary Dasso Mechanism and Regulation of Eukaryotic Protein Synthesis: Thomas Dever Transcriptional and Translational Control Mechanisms in Nutrient Regulation of Gene Expression: Alan Hinnebusch Epigenetic Gene Silencing: Rohinton Kamakaka Molecular Mechanism of Neuronal Connectivity: Chi-Hon Lee Retrotransposons as Models for the Replication of Retroviruses: Henry Levin Molecular Mechanism of Frog Metamorphosis: Yun-Bo Shi Control of Chromosome Transmission Fidelity by the SMC Protein Complexes: Alexander Strunnikov Laboratory of Genomic Integrity Studies on DNA Replication, Repair and Mutagenesis in Eukaryotic and Prokaryotic Cells: Roger Woodgate Laboratory of Integrative and Medical Biophysics Tissue Biophysics and Biomimetics: Peter Basser Medical Biophysics: Robert Bonner Applications of Photon Migration to Tissue Tomography and Spectroscopy: Amir Gandjbakhche Cell Biophysics: Ralph Nossal Laboratory of Mammalian Genes and Development Signals Regulating T Cell Development: Paul Love Molecular Genetics of an Imprinted Gene Cluster on Mouse Distal Chromosome 7: Karl Pfeifer Mammalian Developmental Genetics: Heiner Westphal Laboratory of Molecular Genetics Nutrient Control of Bacterial Gene Expression: Michael Cashel Patterning Neurogenesis in the Zebrafish Embryo: Ajay Chitnis Physiological, Biochemical, and Molecular Genetic Events of Recognition and Resolution of RNA-DNA Hybrids: Robert Crouch Molecular Genetics of Embryogenesis in Xenopus and Zebrafish: Igor Dawid Control of Gene Expression During Development: Judith Kassis Regulation of Homeotic Genes in Drosophila: James Kennison Molecular Genetics of Mammalian Retrovirus Replication: Judith Levin Control of Ectodermal Development in Xenopus: Thomas Sargent Organogenesis of the Zebrafish Vasculature: Brant Weinstein Mechanisms for Controlling Gene Expression in Bacteria and Bacteriophage: Robert Weisberg Laboratory of Molecular Growth Regulation Regulation of DNA Replication and Gene Expression During Animal Development: Melvin DePamphilis Mapping Higher Order Chromatin Structures: Bruce Howard Mechanisms of Eukaryotic RNA Expression and Functions of the Human La Antigen: Richard Maraia Developmental Gene Regulation of the Immune System: Keiko Ozato Gene Activation in Yeast:Targeted Histone Acetylation and Remodeled Chromatin Domains: David Clark The Laboratory of Physical and Structural Biology Biophysics of Large Membrane Channels: Sergey Bezrukov Physical Forces Organizing Biomolecules: Adrian Parsegian Intermolecular Forces, Recognition, and Dynamics: Donald Rau Pediatric and Reproductive Endocrinology Branch The Hypothalamic-Pituitary-Adrenal Axis: Its Endocrine Disorders and Its Interactions with the Immune System: George Chrousos Hypercortiolism and Reproductive Disorders: Lynnette Nieman Diagnosis, Pathophysiology, and Molecular Biology of Pheochromocytoma: Karel Pacak Reproductive Endocrinology and Infertility: James Segars Perinatology Research Branch Pathophysiology of Premature Labor and Complications of Prematurity and Prenatal Diagnosis of Congenital Anomalies: Roberto Romero Physical Disabilities Branch Research in Physical Disabilities: Steven Stanhope Section on Physical Biochemistry Physical Principles of Biomolecular Recognition, Self-Assembly, and Regulation: Sergey Leikin Section on Nervous System Development and Plasticity Nervous System Development and Plasticity: Douglas Fields Section on Cell Biology and Signal Transduction Calcium-Based Excitability in Glial Cells: James Russell