Board of Scientific Counselors

Scientific Director’s Preface

Overview of the Year's Institutional Achievements

Cell Biology and Metabolism Branch
Protein Trafficking in the Endosomal-Lysosomal System: Juan Bonifacino
Cell Cycle Regulation in Oogenesis: Mary Lilly
Roles of the Sec7 Domain ARF GTPase Exchange Factors in Membrane Trafficking: Catherine Jackson
Localization and Dynamics of Intracellular Organelles: Jennifer Lippincott-Schwartz
Gene Regulation in Response to Environmental Signals: Gisela Storz
Regulation of Intracellular Iron Metabolism: Tracey Rouault
VHL Tumor Suppressor Gene: Richard Klausner

Developmental Endocrinology Branch
Growth and Metabolism: Carolyn Bondy
Women’s Health: Carolyn Bondy
The Menstrual Cycle and Human Reproduction: Lawrence Nelson
Cellular and Molecular Mechanisms of Bone Growth: Jeffrey Baron
Neuroendocrinology of Stress: Greti Aguilera
Growth and Obesity: Jack Yanovski
Endocrine Genetics: Constantine Stratakis

Endocrinology and Reproduction Research Branch
Phosphoinositide-Calcium Signaling in Cell Regulation: Tamás Balla
Peptide Hormone Receptors and Signal Transduction: Kevin Catt
Structure and Function of Peptide and Protein Hormones: Hao-Chia Chen
Gonadal Receptors and Mechanism of Action of Peptide Hormones in Steroidogenic Cells: Maria Dufau
Signal Transduction In Synaptic Transmission: Kuo-Ping Huang
Intracellular Signaling in Endocrine and Neuroendocrine Cells: Stanko Stojilkovic
The Biotransformation of Endobiotics bv Sulfonation: Charles Strott

Heritable Disorders Branch
Connective Tissue Disorders: Joan Marini
Inborn Errors of Metabolism: William Gahl
Molecular Biology of Dysmorphology: Forbes Porter
Molecular Genetics of Heritable Human Disorders: Janice Chou
Heritable Disorders of Phospholipid Metabolism and of the Lipid Modification of Proteins: Anil Mukherjee
Genetic Disorders of Drug Metabolism: Ida Owens

Laboratory of Cellular and Molecular Biophysics
The Mechanism of Exocytosis: Joshua Zimmerberg
Membrane Intermediates in Biological Fusion: Leonid Chernomordik
Transfer of Protein from Electrophoretic Bands into Mass Spectrometry by Direct Electroelution: Andreas Chrambach
Protein/Peptide Mass Spectrometry: Alfred Yergey
Cell Interactions in Three-Dimensional Tissue Culture: Leonid Margolis

Laboratory of Cellular and Molecular Neurophysiology
Structure and Function of Glutamate Receptors: Mark Mayer

Laboratory of Cellular and Synaptic Neurophysiology
Hippocampal Interneurons and Their Role in Controlling Excitability: Chris Mcbain
Regulation of Neuronal Gene Expression by Action Potentials: Douglas Fields
Regulation of Glial Development in the Central Nervous System: Vittorio Gallo
Neurotrophic Regulation of Synapse Development and Plasticity: Bai Lu
Second Messenger Systems in Glia and Pineal Cells: James Russell

Laboratory of Comparative Ethology
Genetic and Environmental Determinants of Primate Biobehavioral Development: Stephen Suomi
Mechanisms Regulating Auditory Communication and Social Behavior in Primates and other Mammals: John Newman
Child and Family Development in the First Two Decades of Life: Marc Bornstein
Child Development in Context: Michael Lamb

Laboratory of Developmental and Molecular Immunity
Vaccines Against Human Pathogenic Bacteria: John Robbins
Human Immune Response to Polysaccharide-Protein Conjugate Vaccines: Rachel Schneerson

Laboratory of Developmental Neurobiology
Protein Trafficking and Secretory Granule Biogenesis in Neuroendocrine Cells: Peng Loh
Transcriptional Mechanisms Regulating Activity-Dependent Gene Expression: Andres Buonanno
Tetanus and Botulinum Neurotoxins and Neuronal Cell Biology: Elaine Neale
Activity-Dependent Selective (Hebbian) Synapse Modulation: Phillip Nelson
Neuropeptide-Mediated Regulation of Development: Douglas Brenneman
Dynamic Regulation of the Melatonin Rhythm Enzyme: David Klein

Laboratory of Gene Regulation and Development
Analysis of the S-Phase Checkpoint in Higher Eukaryotes: Mary Dasso
Mechanism and Regulation of Eukaryotic Protein Synthesis: Thomas Dever
Transcriptional and Translational Regulatory Mechanisms in Nutrient Control of Gene Expression: Alan Hinnebusch
Epigenetic Gene Silencing: Rohinton Kamakaka

Molecular Genetics of Retrotransposons: Henry Levin
Molecular Analysis of Frog Metamorphosis: Yun-Bo Shi
The Role of Smc-Family Proteins and Associated Factors in Chromosome Segregation: Alexander Strunnikov

Laboratory of Integrative and Medical Biophysics
Cell Biophysics: Ralph Nossal
Medical Biophysics: Robert F Bonner
Quantitative Optical Imaging and Spectroscopy: Amir Gandjbakhche
Tissue Biophysics and Biomimetics: Peter Basser

Laboratory of Mammalian Genes and Development
Genes That Fashion the Mouse Embryo: Heiner Westphal
Signals Regulating T Cell Development: Paul Love
Molecular Genetics of an Imprinted Gene Cluster on Mouse Distal Chromosome 7: Karl Pfeifer

Laboratory of Molecular Genetics
Molecular Genetics of Embryogenesis in Xenopus And Zebrafish: Igor Dawid
Regulation of Spatial Organization and Terminal Differentiation in Vertebrate Embryos: Thomas Sargent
Vertebrate Neural Development: Ajay Chitnis
The Formation of the Vascular System in Zebrafish: Brant Weinstein
Control of Gene Expression During Development: Judith Kassis
Regulation of Homeotic Genes in Drosophila: James Kennison
Integrative Control of Macromolecular Synthesis: Michael Cashel
Use of RNA-DNA Hybrids for Replication and Repair of DNA and as Drug Therapy: Robert Crouch
Molecular Genetics of Mammlian Retrovirus Replication: Judith G. Levin
The Mechanism and Control of Transciption Termination: Robert Weisberg

Laboratory of Molecular Growth Regulation
Developmental Gene Regulation of the Immune System: Keiko Ozato
Mechanisms of Eukaryotic RNA Expression and Functions of the Human La Antigen: Richard Maraia
Gene Expression at the Beginning of Mammalian Development: Melvin Depamphilis
Control of Mammalian Cell Proliferation: Bruce Howard

The Laboratory of Physical and Structural Biology
Physical Forces Organizing Biomolecules: Adrian Parsegian
Direct Measurement and Computation of Forces Between Membranes or Macromolecules: Donald Rau
Biophysics of Large Membrane Channels: Sergey Bezrukov
Physical Principles of Biomolecular Recognition, Self-Assembly, and Regulation: Sergey Leikin

Pediatric And Reproductive Endocrinology Branch
Hereditary Endocrine Disorders of the HPA Axis: George Chrousos
Interactions Between the Immune System and the HPA Axis: George Chrousos
Molecular Biology, Histology, Biochemistry, and Localization of Pheochromocytoma: Karel Pacak
The Physiology of Hypercortisolism: Lynnette Nieman
Reproductive Endocrinology and Infertility: James Segars

Perinatology Research Branch
Pathophysiology of Premature Labor and Complications of Prematurity: Roberto Romero
Prenatal Diagnosis of Congenital Anomalies: Roberto Romero

Section on Developmental Genomics
Developmental Genomics: Wai-Yee Chan

Section on DNA Replication, Repair and Mutagenesis
DNA Replication, Repair, and Mutagenesis: Roger Woodgate