Skip navigation links
NIGMS Home | Site Map | Staff Search

Results: NIGMS Research Around the Nation

Subscribe to this page: RSS News Feed | Help

View By Date:   From:  From Date    To:  To Date      

May 2008
Rho Keeps Bacterial Genome Tidy
May 15, 2008 • NYU Langone Medical Center

A new study led by NIGMS-supported researchers has revealed that the Rho protein maintains boundaries between genes in the bacterium.

The Wizardry of Green
May 14, 2008 • University of North Carolina

NIGMS-supported scientist, Jeffery Dangl, works to uncover how plants recognize and resist pathogens.

Compound Could Lead to New Class of AIDS Drugs
May 14, 2008 • University of Michigan

NIGMS-supported researchers have developed what they believe is the first new mechanism in nearly 20 years for inhibiting HIV protease, a key viral enzyme.

A Fight to the Death
May 14, 2008 • University of North Carolina

NIGMS-supported neuroscientist, Mohanish Deshmukh, is striving to understand how mammalian cells—both normal and cancerous—activate the programmed cell death pathway and die by apoptosis.

Scientists Uncover New Roles for Small RNAs
May 13, 2008 • Cold Spring Harbor Laboratory

NIGMS-supported scientists have uncovered a new class of small RNAs that modify gene activity and suppress transposable elements. They have also revealed a new source of small RNAs: pseudogenes.

Motor Protein Helps Choreograph Dance of Chromosomes
May 13, 2008 • University of Illinois

In a new NIGMS-supported study, researchers report on how a key motor protein orchestrates chromosome movements at a critical stage of cell division.

Roadblock to Gene Expression
May 9, 2008 • Penn State

NIGMS-funded researchers have discovered a key stop sign for transcription based on nucleosome organization.

Virus Mimics Human Protein
May 8, 2008 • University of Wisconsin, Madison

An NIGMS-funded study has discovered that human cytomegalovirus can mimic a common regulatory protein to hijack normal cell division machinery.

Multicellular Response is "All for One"
May 8, 2008 • Northwestern University

Using C. elegans worms, NIGMS-funded researchers discovered that two specialized neurons sense temperature stress and organize an integrated response for the entire animal.

The Roles of HIV Reverse Transcriptase
May 7, 2008 • Harvard University

An NIGMS-funded study used single-molecule fluorescent imaging to trace the role of reverse transcriptase in real time.

Scientists Launch EcoliHub
May 7, 2008 • Purdue University

With support from NIGMS, scientists have launched a comprehensive online information hub about the E. coli bacterium, one of the most valuable model organisms for biomedical research.

Scientists Establish E. coli Online Resource
May 7, 2008 • National Institute of General Medical Sciences

The new comprehensive resource, EcoliHub, provides a single point of entry to information on the K-12 strain of the bacterium. 

Conserved Molecules Maintain Energy Balance
May 7, 2008 • Salk Institute

Using fruit flies, NIGMS-funded researchers studied molecules that have a role in maintaining energy balance in humans as well.

Identical Genes Behave Differently in Mouse and Human
May 6, 2008 • University of Michigan

While mice and humans are closely related at the genetic level, mice can live without certain genes that are essential to humans, according to a new NIGMS-supported study.

Blocking Brain Enzyme Decreases Appetite
May 6, 2008 • Duke University Medical Center

By blocking a brain enzyme in mice, NIGMS-funded researchers reduced the animals' appetite and their weight.

The Origin of Centrosomes
May 5, 2008 • Marine Biological Laboratory

NIGMS-funded researchers discovered that centrosomes contain RNA that suggests these organelles were incorporated into cells by symbiosis.

Controlling Embryonic Fate by Association
May 4, 2008 • Baylor College of Medicine

An NIGMS-funded study explored how two critical embryonic cell proteins help maintain stem cells in their flexible state.

Long-Time NIGMS Grantees Win Albany Medical Prize
May 2, 2008 • Albany Medical Center

Joan Steitz of Yale University and Elizabeth Blackburn of the University of California, San Francisco, are the first women to win the Albany Medical Center Prize in Medicine and Biomedical Research, America’s largest prize in medicine.

Glowing Sugars in Live Fish
May 2, 2008 • University of California, Berkeley

NIGMS-funded chemists have created glow-in-the-dark zebrafish whose cell-surface carbohydrates are tagged with dyes, a technique that can be used to track development.

April 2008
New Targets for Histone-Modifying Enzymes
April 27, 2008 • Emory University

NIGMS-funded researchers have discovered new molecular targets for an enzyme that modifies chromatin.

Mitochondria Drive Cell Division
April 25, 2008 • Texas A&M University

Studying yeast cells, NIGMS-funded researchers have discovered that mitochondria trigger nuclear DNA to replicate, instigating cell division.

Molecular Analysis Supports T. Rex Link to Birds
April 24, 2008 • Harvard University

Researchers supported in part by NIGMS sequenced collagen protein to analyze the ancestry of Tyrannosaurus rex, finding the dinosaurs to be closer to birds than reptiles.

Structure of DNA Repair Proteins
April 23, 2008 • University of Chicago

NIGMS-funded researchers have determined the atomic structures of DNA-repair proteins that repair damage caused by certain cancer treatments.

Heparin Contaminant Can Cause Reactions
April 23, 2008 • National Institute of General Medical Sciences

Scientist clarified the possible biological link between a contaminant recently found in some lots of heparin and allergy-like reactions including deaths. Some of the same scientists also determined the chemical structure of the contaminant, which will aid in detecting it.

RNA Interference and Epigenetic Inheritance
April 22, 2008 • Cold Spring Harbor Laboratory

An NIGMS-funded study probes how interfering RNA molecules allow DNA expression patterns to be inherited.

Environment Plays a Large Role in Human Gene Activity
April 22, 2008 • North Carolina State University

An NIGMS-funded study found that up to one-third of genes' expression varies depending on where and how Berbers in Morocco live.

How Cells Defend Against Genetic Mistakes
April 17, 2008 • University of Rochester Medical Center

NIGMS-funded researchers have discovered a step whereby cells find flawed mRNAs to prevent the production of damaged proteins.

How Bacteria Divide
April 17, 2008 • Duke University Medical Center

In work that could lead to new antibiotics, NIGMS-funded researchers have demonstrated the key role of a protein involved in bacterial cell division.

A More Detailed View of Chromatin Structure
April 16, 2008 • University of Illinois at Urbana-Champaign

NIGMS-funded researchers have developed a technique that reveals a sharper image of chromatin, the bundles of genetic material and protein that make up chromosomes.

Launching a Global Alliance for Pharmacogenomics
April 14, 2008 • National Institute of General Medical Sciences

U.S. and Japanese scientists partner to study genetic factors that influence the safety and effectiveness of medicines. 

Target for Inhibiting Necrosis
April 11, 2008 • Tufts University

A study funded in part by NIGMS reveals that a kinase protein can direct cells into cell death, for example after a heart attack or stroke.

How Heart Protein Works
April 10, 2008 • University of Pennsylvania School of Medicine

An NIGMS-funded study has discovered how a protein called leiomodin directs the assembly of actin to allow the pumping of the heart.

How Closing Schools Might Affect a Flu Pandemic
April 9, 2008 • Imperial College London

NIGMS-funded researchers have calculated the impact of school closures on the spread of a future flu pandemic.

A Fingerprint of Evolution in the Human Genome
April 8, 2008 • Cold Spring Harbor Laboratory

At least a third of the genome is affected by "fingerprints" that are conserved even though they don't code for protein, reports an NIGMS-funded study.

Visualizing the Machinery of mRNA Splicing
April 4, 2008 • Yale University

NIGMS-funded researchers have solved the crystal structure of a a self-splicing region of RNA, providing a glimpse of an ancient mechanism.

Selenium Supplements May Not be Useful
April 4, 2008 • University of Nebraska, Lincoln

By conducting a genetic analysis in a broad range of animals, NIGMS-funded researchers suggest that mammals may need little selenium.

Potential Approach to Treat Spinal Muscular Atrophy
April 4, 2008 • Cold Spring Harbor Laboratory

NIGMS-funded researchers induced cells to replenish a protein without which there is damage to growing nerve cells and the muscles they control.

New Web Portal to Advance Wide Range of Protein Studies
April 3, 2008 • National Institute of General Medical Sciences

The Protein Structure Initiative has launched an online resource that will enable scientists from across biomedical disciplines to easily access a wealth of information about proteins.

How Plants Step Out of the Shade
April 3, 2008 • Salk Institute

An NIGMS-funded study has clarified the molecular steps that allow a plant to stretch out of the shade toward the sun.

Mechanism Underlying Multidrug Resistance in Fungi
April 2, 2008 • Massachusetts General Hospital

An NIGMS-funded study has identified a molecular switch that causes drug-resistance in fungi, which can plague people with compromised immunity.

March 2008
Technique Identifies Biomarkers for Disease
March 31, 2008 • University of Florida

NIGMS-funded researchers have developed a technique for finding markers for disease without any advance knowledge of the molecules.

Replacing microRNAs Could Treat Cancer
March 31, 2008 • University of Chicago

Small, non-coding RNAs appear to be a master regulator without which many types of cells become cancerous, reports an NIGMS-funded study.

Cellulose, the Paper Trail of Life
March 31, 2008 • University of North Carolina at Chapel Hill

An NIGMS-funded researcher suggests that cellulose, made by plants, algae and certain bacteria, could be a durable marker for life on other planets.

An Automated Way to Determine Possible Drug Structures
March 31, 2008 • University of California, San Diego

An NIGMS-funded study reports a way to quickly determine the structure of natural peptides, which have shown promise as all kinds of drugs.

Ant Guts Could Show Way for Better Drugs
March 25, 2008 • Princeton University

By studying microbes from the guts of carpenter ants, NIGMS-funded researchers discovered two proteins that help form bacteria's outer shells.

Algae Point to Possible Malaria Vaccine
March 25, 2008 • University of Texas Southwestern Medical Center

An NIGMS-funded study of reproduction in a harmless type of algae revealed a mechanism similar to that used by the malaria parasite.

How Bacteria Team Up to Form a Biofilm
March 24, 2008 • Cornell University

NIGMS-funded researchers have identified a kind of bacterial signalling system that allows the formation of biofilms, which allow bacteria to evade antibiotics and the immune systems of their hosts.

The Uncharted Arena of Human-Only Genes
March 21, 2008 • Washington University

An NIGMS-funded study produced the first detailed analysis of one of the few genes found only in hominoids.

Nutrient Status Affects Biological Clock
March 20, 2008 • New York University

Using a systems biology approach, a team of NIGMS-supported researchers has revealed that the master gene that controls the biological clock in Arabidopsis is sensitive to nutrient status.

Jumping Gene May Contribute to Aging Syndrome
March 20, 2008 • University of Washington

NIGMS-funded researchers have discovered a transposon that has settled into a gene linked to Cockayne syndrome, which causes premature aging.

First 3-D View of Anti-Cancer Agent
March 18, 2008 • Indiana University

An NIGMS-funded study shows how bleomycin, an established chemotherapy agent, binds to DNA, a finding that may help in the development of future cancer drugs.

Gene Involved in Male Infertility Identified
March 14, 2008 • University of Pennsylvania

A team of NIGMS-supported scientists has identified an X chromosome gene involved in meiosis that when disrupted renders male mice sterile and female mice less fecund.

Study Helps Explain Tumor Growth
March 13, 2008 • Beth Israel Deaconess Medical Center

NIGMS-supported researchers have discovered that a metabolic process known as the Warburg effect is essential for tumors’ rapid growth, and involves an enzyme called pyruvate kinase M2.

Structure Reveals How Cells 'Sugar-Coat' Proteins
March 11, 2008 • Brookhaven National Laboratory

A team of NIGMS-supported scientists has deciphered the structure of a large protein complex responsible for adding sugar molecules to newly formed proteins.

Biologists Identify Key Protein in Cell’s “Self-Eating” Function
March 11, 2008 • University of California, San Diego

NIGMS-supported molecular biologists have found one piece of the complex puzzle of autophagy, the process of “self-eating” performed by all eukaryotic cells to keep themselves healthy.

Scientists Simulate Flu Outbreak in City Similar to Chicago
March 10, 2008 • Fred Hutchinson Cancer Research Center

Antiviral medications and social-distancing measures may be sufficient to mitigate a flu pandemic outbreak until a vaccine becomes available, according to a new NIGMS-supported study.

Twice the Telomere Options in Roundworms
March 6, 2008 • Salk Institute

NIGMS-funded researchers have discovered that C. elegans can cap their chromosomes with two different types of telomeres, a finding with implications for aging and cancer.

Chronically High Blood Sugar Levels Dull Insulin Response
March 6, 2008 • Salk Institute

An NIGMS-funded study explores the biochemical vicious circle in which high blood sugar levels disable the body's response to rising levels of insulin.

Researchers Identify Genetic Variation to Predict Initial Response to Warfarin
March 5, 2008 • NHLBI Communications Office

NIGMS-funded scientists have identified which variations of a specific gene determine a patient’s initial response to treatment with the blood-thinning (anticoagulant) drug warfarin.

Genomic Exchanges Linked to Flu Epidemics
March 4, 2008 • Penn State

An NIGMS-funded study reports that the swapping of genetic material between closely related flu strains--not just ones infecting different species--can trigger epidemics.

February 2008
Mystery of Glowing Antibody Solved
February 28, 2008 • Scripps Research Institute

NIGMS-funded scientists have discovered the rare and rather surprising mechanism behind the bright blue glow of a fluorescent antibody, which could be applied to the development of biosensors.

Gene Expression Differences Affect Response to Drugs, Infections
February 28, 2008 • University of Chicago Medical Center

Researchers in the NIGMS-funded Pharmacogenetics Research Network have found that differences in gene expression levels between population groups can affect how they respond to drugs or fight off specific infections.

Ozone-Resistance Gene Could Lead to Drought-Resistant Crops
February 27, 2008 • University of California, San Diego

NIGMS-funded researchers have elucidated the mechanism of a plant gene that controls the amount of ozone that enters a plant's leaves.

Understanding Antibiotic Resistance
February 25, 2008 • Ohio State University

NIGMS-funded researchers have identified the role of two proteins that allow bacteria to resist some antibiotics.

Model Reveals Mechanism Behind Blood Clot Elasticity
February 25, 2008 • University of Illinois at Urbana-Champaign

Using a detailed computational approach, NIGMS-funded researchers have modeled why the clotting protein fibrinogen is so elastic.

Protein "Shocks" Evolution Into Action
February 23, 2008 • Whitehead Institute for Biomedical Research

A heat shock protein could act as a key pivot on which evolution acts, report NIGMS-funded researchers.

New Details About a Gene Network Governing Metabolism
February 22, 2008 • Cold Spring Harbor Laboratory

An NIGMS-funded study found an unexpected wrinkle in how yeast cells, through their genes, adjust their metabolism in response to changing food sources.

Study Canvasses Human Genetic Variation Around Globe
February 20, 2008 • University of Michigan

NIGMS-funded researchers have helped produce the largest and most detailed worldwide survey of human genetic variation, uncovering clues to human origins.

New Tool Probes Cellular Oxidative Stress
February 20, 2008 • University of Michigan

Scientists supported by NIGMS have developed a new method to observe how oxidative stress affects the major building blocks of a cell, the proteins.

Migration from Africa Left Mark on European Genetic Diversity
February 20, 2008 • Cornell University

An NIGMS-funded study examining genetic variation found unexpected differences between European-Americans and African-Americans.

Genetic Pathway Involved in Oxidative Stress, Disease
February 20, 2008 • University of Wisconsin, Madison

NIGMS-funded researchers have discovered a genetic pathway that influences cells' response to oxidative stress, a process that contributes to a host of diseases.

Study Explains Spread of 1918 Flu
February 18, 2008 • Massachusetts Institute of Technology

Two mutations in a surface molecule of the 1918 pandemic flu strain dramatically changed the affinity of the virus to human receptors, reports an NIGMS-funded study.

Novel Approach Strips Staph of Virulence
February 14, 2008 • National Institute of General Medical Sciences

An international team of researchers supported by NIH has blocked staph infections in mice using a drug previously tested in clinical trials as a cholesterol-lowering agent. The novel approach could offer a new direction for therapies against a bacterium that’s becoming increasingly resistant to antibiotics.

Enzyme Structure Reveals New Drug Targets for Cancer and Other Diseases
February 14, 2008 • National Institute of General Medical Sciences

NIGMS-funded scientists now have a clearer understanding of how a key protein (p300/CBP) controls gene activity and how mutations in the protein may cause disease. The work could provide new avenues to design drugs aimed at cancer, diabetes, HIV, and heart disease.

Folding of RNA Molecule Observed in Real Time
February 13, 2008 • Stanford University

NIGMS-supported scientists have used a device called an optical trap to observe in real time the folding of a riboswitch, a type of RNA molecule.

Bacterial Toxin Closes Gate on Immune Response
February 13, 2008 • University of Pennsylvania School of Medicine

A toxin from the bacterium Staphylococcus aureus shuts down a type of ion channel key to mounting an immune response, according to a new NIGMS-supported study. 

Gene Chips Used to Recognize Ventilator-Associated Pneumonia
February 12, 2008 • Washington University in St. Louis

Using gene chip technology, a team of NIGMS-supported scientists has distinguished pneumonia associated with ventilator use from other serious illnesses.

Discovery of 'Overdrive' Protein Could Broaden Drug Design Options
February 12, 2008 •  University of North Carolina at Chapel Hill

A team of NIGMS-supported scientists has revealed that a protein called Arr4 can sustain the activity of G-protein signaling pathways, which are targeted by a number of commonly used medicines.

Scientists Use Engineering Approach to Study Biological Pathways
February 6, 2008 • Massachusetts Institute of Technology

An NIGMS-supported team of scientists has analyzed a complex biological system by treating it as a “black box,” an approach commonly used in engineering disciplines.

Scientists Determine Protein Structure Key to Huntington's Disease
February 4, 2008 • Indiana University

NIGMS-supported scientists have determined the structure of a key part of HIP1, a protein that is implicated in Huntington's disease.

Computational Approach Could Help Identify Drug Targets
February 1, 2008 • University of Chicago Medical Center

NIGMS-supported researchers have analyzed the proteins targeted by nearly a thousand FDA-approved drugs and identified characteristics shared among successful drug targets.

January 2008
Genetic Recombination Varies Among Individuals
January 31, 2008 • University of Chicago Medical Center

A new study supported by NIGMS has uncovered remarkably high levels of individual variation in recombination, the process by which parents pass on a mosaic-like mixture of their genes.

Scientists Propose New Model for Ion Channel Regulation
January 30, 2008 • Rush University Medical Center

A study supported by NIGMS proposes that bubbles may control the opening and closing of ion channels, conduits that controls a wide range of biological functions.

Researchers Uncover New Way to Target Flu
January 30, 2008 • University of Pennsylvania School of Medicine

A team of researchers supported by NIGMS has solved the three-dimensional structure of an influenza protein called M2. The findings offer new ways to target drug-resistant influenza.

Gene Discovery Made Easier With New Networking Technique
January 29, 2008 • University of Texas at Austin

NIGMS-supported researchers have used a new gene networking model they developed to identify genes that regulate life span and affect tumor development in the nematode worm.

Scientists Explore Factors Contributing to DNA Mutations
January 28, 2008 • Pennsylvania State University

A team of NIGMS-supported researchers has conducted a genome-wide study comparing the relative importance of factors that contribute to DNA mutations, which are implicated in cancer and other diseases.

Novel Genes ‘Notch’ Glucose into Place
January 25, 2008 • Baylor College of Medicine

A novel gene called Rumi regulates the Notch protein by adding a glucose molecule to the part of Notch that extends outside the cell, according to a new NIGMS-supported study.

NIGMS Strategic Plan Reinforces Commitment to Investigator-Initiated Research
January 25, 2008 • National Institute of General Medical Sciences

NIGMS has issued Investing in Discovery, a strategic plan that will guide the Institute’s decision-making over the next 5 years.

Scientists Develop Tools to Breed Maize Rich in Provitamin A
January 24, 2008 • Lehman College

A team of NIGMS-supported scientists has identified DNA-based indicators for high provitamin A production that breeders can use in maize breeding programs.

New Members Appointed to NAGMS Council
January 24, 2008 • National Institute of General Medical Sciences

Three new members were appointed to the National Advisory General Medical Sciences Council. They are Mariano A. Garcia-Blanco, M.D., Ph.D., of Duke University Medical Center, Durham; Howard H. Garrison, Ph.D., of the Federation of American Societies for Experimental Biology, Bethesda; and Alejandro Sánchez Alvarado, Ph.D., of University of Utah School of Medicine, Salt Lake City. 

Scientists Challenge RNA Decay Model
January 18, 2008 • Case Western Reserve University

A new NIGMS-supported study challenges molecular biology’s widely-accepted model for nonsense-mediated messenger ribonucleic acid (mRNA) decay.

Scientists Uncover Role of Gene Linked to Aggressive Cancer
January 17, 2008 • Thomas Jefferson University

NIGMS-supported researchers have revealed the function of a gene previously shown to be part of an 11-gene “signature” that can predict which tumors will be aggressive and likely to spread.

Alzheimer’s Molecule Implicated in Nerve Cell Transport
January 17, 2008 • University of Pennsylvania School of Medicine

NIGMS-supported researchers have discovered that proteins carrying chemical cargo in nerve cells react differently when exposed to the tau protein, which plays an important role in Alzheimer’s disease.

Calcium Channel Helps Trigger Allergic Reactions
January 14, 2008 • Beth Israel Deaconess Medical Center

Mice lacking the CRACM1 calcium channel are resistant to stimuli that typically elicit severe allergic reactions, according to an NIGMS-supported study.

Equation Shows How Cells Create Fly Eye
January 11, 2008 • Northwestern University

A mathematician and biologist, funded by NIGMS, have created a mathematical model for how cells pack together to create the eyes of Drosophila.

Different Pathways Govern Onset and Offset of Anesthesia
January 11, 2008 • University of Pennsylvania School of Medicine

A team of NIGMS-supported researchers has shown that the cellular pathway for emerging from general anesthesia is different from the one that drugs take to put patients to sleep.

Nanotechnology To Detect Gene Expression
January 10, 2008 • Arizona State University

Using self-assembled DNA nanostructures, NIGMS-funded researchers are developing new and sensititve ways to detect gene expression.

Interactions of Stem Cells With Their Niche
January 10, 2008 • Stowers Institute for Medical Research

NIGMS-funded researchers are beginning to understand how stem cells interact with their microenvironment.

Genes Stay Put For Transcription
January 8, 2008 • Cornell University

NIGMS-funded researchers have evidence that transcription machinery moves to genes instead of genes having to move to specific locations in the nuclei to be expressed.

Study of Sugars on Cell Surface Identifies Key Factor in Flu Infection
January 7, 2008 • National Institute of General Medical Sciences

NIGMS-supported scientists have identified a key factor that determines the ability of influenza viruses to infect cells of the human upper respiratory tract.

Structure of Enzyme Mutated in Many Cancers
January 4, 2008 • Johns Hopkins Medical Institutions

NIGMS-funded researchers have solved the structure of an enzyme (PIK3CA) that is mutated in cancers of the colon, brain, stomach, breast, lung, and others.

A Route for Heredity Bypassing DNA
January 4, 2008 • Princeton University

Using a single-celled ciliate, NIGMS-funded biologists have discovered a mechanism whereby genetic information can be passed on through generations via RNA.

How Cells Regulate Hydrogen Peroxide
January 2, 2008 • Wake Forest University Baptist Medical Center

A snapshot of how two proteins interact, determined by NIGMS-funded researchers, helps show how cells control levels of hydrogen peroxide.

December 2007
Unusual Plant Gene Disrupts Fertilization
December 20, 2007 • University of California, San Diego

NIGMS-funded biologists have discovered a gene in plants that disrupts fertilization only when the gene is mutated in both female and male reproductive cells.

Structure Crucial to Chromosome Segregation
December 20, 2007 • University of Texas M. D. Anderson Cancer Center

NIGMS-funded researchers have solved the structure of a DNA-protein complex necessary for chromosome separation and involved in the spread of antibiotic resistance.

Stem Cell Advance Tops 2007 Lists
December 20, 2007 • National Institute of General Medical Sciences

A stem cell research breakthrough partially supported by NIGMS is tops on two lists of science advances made during 2007.

Disorders May Be Linked to Protein Recycling System
December 20, 2007 • Cincinnati Children's Hospital Medical Center

Failures in a recycling system for Wnt signaling proteins may be responsible for diseases ranging from cancer to birth defects, report NIGMS-funded researchers.

Overexcited Neurons Can Damage Cells
December 17, 2007 • Northwestern University

Excessive neuronal signaling can damage proteins in target cells, similar to the effects of exposure to nicotine or a pesticide, report NIGMS-funded researchers.

Molecular Machinery Allows Histones to Talk
December 14, 2007 • Stowers Institute for Medical Research

NIGMS-funded researchers have new findings on how histones, which package DNA and help regulate gene expression, communicate with each other.

How Molecular Muscles Pinch Cells in Two
December 14, 2007 • Yale University

Observing live cells, NIGMS-funded researchers have studied how cells assemble contractile rings during cell division.

Genetic Pathways Involved in Form of Cell Suicide
December 14, 2007 • University of Massachusetts Medical School

Using fly salivary glands, NIGMS-funded researchers are studying autophagy, a form of programmed cell death required for healthy development.

Protein Dynamics in MAP Kinase Signaling Pathway
December 13, 2007 • Stowers Institute for Medical Research

Using sophisticated techniques on live cells, NIGMS-funded researchers measured protein interactions in the critical MAP kinase signaling pathway.

Switch Triggers Circadian Rhythms
December 12, 2007 • University of California, Irvine

NIGMS-funded researchers have discovered that the modification of a single amino acid triggers the genetic chain of events involved with circadian rhythms.

Seeing Enzymes in Real Time
December 11, 2007 • Brandeis University

NIGMS-funded researchers were able to watch an enzyme as it changed shape in the absence of a substrate.

More Regulatory DNA in Genome Than Expected
December 11, 2007 • Johns Hopkins Medical Institutions

Current computer programs that scan the genome for regulatory DNA can miss more than half of these regions, report NIGMS-funded researchers.

Computational Technique Can Predict Drug Side Effects
December 11, 2007 • University of California, San Diego

Scanning candidate drugs against the Protein Data Bank can be used to predict side effects, NIGMS-funded researchers say.

Switch Regulates Trafficking Within Cells
December 10, 2007 • Weill Cornell Medical College

NIGMS-funded researchers have discovered a molecular "switch" in epithelial cells that selects from motor proteins called kinesins to traffic materials to the cell surface.

Protein Protects Brain Against Lead, Liver Disease
December 6, 2007 • University of Michigan

Using mice, NIGMS-funded researchers discovered that a protein (PEPT2) protects brains from lead poisoning and liver diseases with neurological effects.

New Software To Aid Early Detection of Infectious Disease Outbreaks
December 6, 2007 • National Institute of General Medical Sciences

A newly released software program will let health authorities at the site of an infectious disease outbreak quickly analyze data, speeding the detection of new cases and the implementation of effective interventions. 

Mechanism Disposes of Faulty Proteins
December 6, 2007 • St. Jude Children's Research Hospital

NIGMS-funded researchers have identified cellular components that help dispose of defective proteins, potentially revealing targets for future cancer drugs.

Nanotechnology Shows Cancer Cells "Feel" Softer
December 2, 2007 • University of California, Los Angeles

Using nanotechnology that measures the softness of cells, NIGMS-funded researchers showed that metastatic cancer cells feel different from normal cells.

November 2007
Snapshot Clarifies How Materials Enter Cells
November 30, 2007 • Purdue University

NIGMS-funded researchers have obtained a snapshot of a tiny protein gate found in cell membranes as material passes through.

Inconspicuous Hosts for Lyme Disease
November 29, 2007 • University of Pennsylvania

NIGMS-funded researchers have shown that chipmunks and two types of shrews, not just mice, are the main animal reservoirs for lyme disease.

Genetics Supports Single Migration Across Bering Strait
November 27, 2007 • University of Michigan Health System

New genetic evidence, uncovered with NIGMS funding, supports the notion that Native Americans descended from a small number of people crossing once from Asia across the Bering Strait.

Cholera Can Be Controlled With Oral Vaccines
November 26, 2007 • Fred Hutchinson Cancer Research Center

Researchers funded by the NIGMS Models of Infectious Disease Agent Study report that cholera could be controlled inexpensively by orally vaccinating affected populations.

Chromosome Coiling Makes Biological Clock Tick?
November 21, 2007 • Vanderbilt University

Working with bacteria, NIGMS-funded researchers discovered a rhythmic day/night cycle in how condensed DNA is.

Scientists Guide Human Skin Cells to Embryonic State
November 20, 2007 • University of Wisconsin, Madison

NIGMS-funded researchers report the genetic reprogramming of human skin cells to create cells indistinguishable from embryonic stem cells, an accomplishment that should speed up stem cell research and remove ethical and legal constraints to their use.

Protein Family is Key to Brain Function
November 19, 2007 • Massachusetts Institute of Technology

NIGMS-funded biologists have discovered a family of proteins that helps direct the formation of axons and dendrites, allowing communication between neurons.

How Embryos Regulate Levels of Vitamin A Derivative
November 19, 2007 • University of California, Irvine

NIGMS-funded research shows how embryonic cells may regulate levels of retinoic acid, a signal that controls the development of many body parts.

This page last updated January 7, 2009