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Sponsored by: |
Northwestern University |
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Information provided by: | Northwestern University |
ClinicalTrials.gov Identifier: | NCT00821132 |
The investigators long term goals are to improve diagnosis and develop effective treatments that arrest or ameliorate symptoms of ALS, and possibly delay or prevent disease onset in individuals at risk for developing familial ALS (FALS). In order to do this one must understand how disease develops at a molecular level. Identification of genes that increase risk for developing all types of ALS will reveal the pathways of molecular events that are involved in ALS.
The investigators are collecting blood samples, family and medical histories of patients familial, sporadic ALS or primary lateral sclerosis(PLS)and particular family members. Samples are coded to maintain confidentiality. Travel is not necessary.
As well as seeking to identify new genes implicated in ALS, the investigators continue our study of families with SOD1-ALS to more fully characterize that disease mechanism.
Linkage analysis and affected relative pair analysis will be used to identify causative FALS genes and disequilibrium analysis and association studies are being done for sporadic ALS.
Results from these studies will provide insight into the underlying disease mechanisms of ALS and provide targets for therapeutic interventions.
Condition | Intervention |
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Amyotrophic Lateral Sclerosis Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia Lou Gehrig's Disease Motor Neuron Disease Primary Lateral Sclerosis |
Other: Genetic study of ALS families |
Study Type: | Observational |
Study Design: | Family-Based |
Official Title: | Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism. |
Whole blood and/or CSF samples
The investigators also have a brain and spinal cord tissue bank.
Estimated Enrollment: | 15000 |
Study Start Date: | January 1991 |
Estimated Study Completion Date: | December 2015 |
Groups/Cohorts | Assigned Interventions |
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ALS families
Patients with either inherited or sporadic ALS or PLS and selected family members
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Other: Genetic study of ALS families
Collection and analysis of genetic material, medical and family histories from families with ALS
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Open to all ALS patients and selected family members
Inclusion Criteria:
Exclusion Criteria:
Contact: Sandra Donkervoort, MS | 312 503 0154 | s-donkervoort@northwestern.edu |
Contact: Nailah Siddique, RN MSN | 312 503 2712 | nsiddique@northwestern.edu |
United States, Illinois | |
Northwestern University Feinberg School of Medicine | Recruiting |
Chicago, Illinois, United States, 60611 | |
Principal Investigator: Teepu Siddique |
Principal Investigator: | Teepu Siddique, MD | Northwestern University Feinberg School of Medicine Neuromuscular Disorders Program |
Responsible Party: | Neuromuscular Disorders Program ( Teepu Siddique, MD ) |
Study ID Numbers: | Lab01, RO1 N505641-04, RO1 ES014469-02, RO1 NS046535 |
Study First Received: | January 9, 2009 |
Last Updated: | January 12, 2009 |
ClinicalTrials.gov Identifier: | NCT00821132 |
Health Authority: | United States: Institutional Review Board |
FALS ALS ALS/FTD SOD |
SALS MND PLS |
Pick Disease of the Brain Frontotemporal dementia Spinal Cord Diseases Brain Diseases Neurodegenerative Diseases Aphasia, Primary Progressive Signs and Symptoms Neuromuscular Diseases Mental Disorders Primary progressive aphasia Dementia Motor Neuron Disease Neurobehavioral Manifestations Delirium Speech Disorders |
Aphasia Central Nervous System Diseases Language Disorders Sclerosis Degenerative motor system disease Motor neuron disease Cognition Disorders Amyotrophic lateral sclerosis Delirium, Dementia, Amnestic, Cognitive Disorders Amyotrophic Lateral Sclerosis Neurologic Manifestations Lou Gehrig's disease Lobar atrophy of brain Pick disease of the brain Communication Disorders |
Pathologic Processes Nervous System Diseases |