The investigators in the Experimental Therapeutics and Pathophysiology Branch conduct clinical and basic research studies on the pathop  hysiology, etiology, and treatment of mood and anxiety disorders. This research group focuses on identifying the neural circuits and neurochemicals that mediate the symptoms associated with mood and anxiety disorders. Children, adolescents, and adults are studied and there is a strong emphasis on the developmental perspective. Investigations utilize a broad range of techniques including neurochemical, neuroendocrine, neurophysiological, and neuroimaging approaches. The genetic epidemiology program applies the tools of epidemiology and genetics to identify risk factors for mood and anxiety disorders, and their association with other psychiatric and medical disorders.

      Patients with bipolar disorder, unipolar depression, posttraumatic stress disorder, social anxiety disorder, generalized anxiety disorder, and panic disorder are studied. Major hypotheses under investigation include the effects of stress on brain structure and function and the role of neuropeptides, growth factors, amino acid and monoamine neurotransmitters in the pathophysiology of mood and anxiety disorders.

      The translation of the basic and clinical findings relevant to pathophysiology into the discovery of novel effective treatments is also of great importance to the branch. Ultimately our goal is to contribute toward improved methods of prevention, diagnosis, and treatment of these common and very serious psychiatric disorders.

Mission Statement

Program Director

Clinical Research Opportunities

Investigators

Program Information

What's New?

Disclaimer

For further information call toll free:
1-866-MAPNIMH
1-866-627-6464