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| Sponsors and Collaborators: |
Kaohsiung Medical University Chung-Ho Memorial Hospital Centers for Disease Control and Prevention |
|---|---|
| Information provided by: | Kaohsiung Medical University Chung-Ho Memorial Hospital |
| ClinicalTrials.gov Identifier: | NCT00688389 |
Purpose
Research has showed that CLEC5A interacts with dengue virion directly, and is responsible for dengue virus (DV)-induced DAP12 phosphorylation. Data suggests that CLEC5A is a potential therapeutic target for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). This project will study the genes of CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), and (Nod)-like receptors (NLRs) for both DF and DHF groups. In addition, serum level of decoy receptor 3 (DcR3) will be tested. The study will collect the blood samples from 150 healthy persons, 150 persons infected with dengue fever, and 150 persons infected with DHF or DSS.
| Condition | Intervention |
|---|---|
|
Dengue Fever |
Genetic: CLEC5A |
| Study Type: | Observational |
| Study Design: | Cohort |
| Official Title: | Follow-up the Health Condition , Investigation of the Immuno-Regulation , and the Study for Interaction of Viral Hepatitis--- Among Patients With or After Dengue Fever Infection |
| Estimated Enrollment: | 450 |
| Study Start Date: | July 2007 |
| Estimated Study Completion Date: | June 2009 |
| Groups/Cohorts | Assigned Interventions |
|---|---|
| healthy | Genetic: CLEC5A |
| DF | Genetic: CLEC5A |
| DHF | Genetic: CLEC5A |
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
The samples are obtained from the Kaohsiung Medical University Chung-Ho Memorial Hospital in Kaohsiung, Taiwan.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Jih-Jin Tsai, MD | 886-7-312-1101 ext 5677 | jijits@cc.kmu.edu.tw |
| Taiwan | |
| Kaoshing Medical University Chung-Ho Memorial Hospital | Recruiting |
| Kaoshiung, Taiwan | |
| Contact: Jih-Jin Tsai, MD 886-7-312-1101 ext 5677 jijits@cc.kmu.edu.tw | |
More Information
| Responsible Party: | Kaohsiung Medical University Chung-Ho Memorial Hospital ( Tsai, Jih-Jin / Dr. ) |
| Study ID Numbers: | KMUH-IRB-960195_1, CB9615 |
| Study First Received: | May 28, 2008 |
| Last Updated: | September 3, 2008 |
| ClinicalTrials.gov Identifier: | NCT00688389 |
| Health Authority: | Taiwan: Institutional Review Board |
|
Dengue fever, CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), (Nod)-like receptors (NLRs) |
|
Liver Diseases Dengue fever Dengue Hemorrhagic Fever Hepatitis Fever Virus Diseases Signs and Symptoms |
Hemorrhagic Fevers, Viral Digestive System Diseases Dengue Hemorrhagic fever Viral hemorrhagic fever Arbovirus Infections |
|
RNA Virus Infections Flaviviridae Infections Flavivirus Infections Body Temperature Changes |
