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Sponsored by: |
Alberta Cancer Board |
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Information provided by: | Alberta Cancer Board |
ClinicalTrials.gov Identifier: | NCT00131599 |
Cancer of the colon and rectum are the third most common cancers in Canadian males and females. The initial therapy of colorectal cancer is surgery to remove the cancer and nearby lymph glands. If the cancer has spread to the lymph glands there is a high chance that the cancer will come back. To reduce the risk of the cancer recurring, patients are treated with an anticancer drug 5-fluorouracil (5FU) in combination with a vitamin leucovorin (LV). This study will determine if a simple blood test can predict which patients are at risk for developing side effects from this chemotherapy. In addition, participants of this study will be followed to determine if this same blood test will predict which patients will have their cancer relapse.
Condition | Intervention |
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Colon Cancer |
Drug: 5FU/LV |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer |
Estimated Enrollment: | 104 |
Study Start Date: | August 2002 |
Estimated Study Completion Date: | December 2005 |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | GI-05-0021 |
Study First Received: | August 17, 2005 |
Last Updated: | September 22, 2008 |
ClinicalTrials.gov Identifier: | NCT00131599 |
Health Authority: | Canada: Health Canada |
5-fluorouracil thymidylate synthase pharmacogenetics |
Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Fluorouracil Colonic Diseases |
Gastrointestinal Neoplasms Intestinal Diseases Colonic Neoplasms Intestinal Neoplasms Colorectal Neoplasms |
Antimetabolites Neoplasms Antimetabolites, Antineoplastic Neoplasms by Site Immunologic Factors Molecular Mechanisms of Pharmacological Action |
Antineoplastic Agents Therapeutic Uses Physiological Effects of Drugs Immunosuppressive Agents Pharmacologic Actions |