CARMEDAS: Cost-Effectiveness Analysis of Imaging Strategies in Symptomatic Carotid Stenosis - Full Text View

Sponsored by:	Hospices Civils de Lyon
Information provided by:	Hospices Civils de Lyon
ClinicalTrials.gov Identifier:	NCT00131001

Purpose

PURPOSE: The purpose of this clinical trial is to study the cost-effectiveness ratios of diagnostic strategies for the imaging assessment of symptomatic carotid stenosis.

MATERIALS AND METHODS: The diagnostic accuracies of Doppler ultrasound (DUS), contrast-enhanced magnetic resonance angiography (CEMRA) and computed tomography angiography (CTA) were compared with digital subtraction angiography (DSA) in a multicenter study (CARMEDAS; 206 patients assessable) and in a meta-analysis (for CEMRA and CTA). The direct costs of each imaging method were calculated in 2 university medical centers. Eight hypothetical models were studied with DUS considered as the first-line imaging method and either CEMRA or CTA or DSA as the second or third line method. The effectiveness criterion was the number of potential avoided strokes for each strategy and for 1000 patients.

Condition	Intervention
Carotid Stenosis	Procedure: contrast-enhanced magnetic resonance angiography

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Diagnostic, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment
Official Title:	Cost-Effectiveness Analysis of Imaging Strategies in Symptomatic Carotid Stenosis

Further study details as provided by Hospices Civils de Lyon:

Primary Outcome Measures:

To study the cost-effectiveness ratios of diagnostic strategies for the imaging assessment of symptomatic carotid stenosis

Estimated Enrollment:	300
Study Start Date:	April 2001

Eligibility

Ages Eligible for Study:	18 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Carotid artery stenosis > 50%

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00131001

Locations

France
Hôpital Louis Pradel
BRON, France, 69677

Sponsors and Collaborators

Hospices Civils de Lyon

Investigators

Principal Investigator:

Philippe DOUEK, MD

Hospices Civils de Lyon

More Information

Study ID Numbers:	99.203
Study First Received:	August 16, 2005
Last Updated:	October 17, 2008
ClinicalTrials.gov Identifier:	NCT00131001
Health Authority:	France: Ministry of Health

Keywords provided by Hospices Civils de Lyon:

Carotid artery stenosis
cost effectiveness
magnetic resonance angiography
computed tomography angiography
digital subtraction angiography

Study placed in the following topic categories:

Pathological Conditions, Anatomical
Arterial Occlusive Diseases
Carotid Stenosis
Vascular Diseases
Central Nervous System Diseases

Constriction, Pathologic
Brain Diseases
Carotid Artery Diseases
Cerebrovascular Disorders

Additional relevant MeSH terms:

Nervous System Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009