Inclusion Criteria:

• Advanced cancer
• Gastric or esophageal cancer
• Adequate organ function and bone marrow reserve
• In general, patients must be 18 years or older
• Life expectancy of > 12 weeks
• World Health Organization (WHO) performance status 0-2
• Left ventricular ejection fraction (LVEF) by multiple gated acquisition (MUGA) > 50%
• Adequate organ function: hematological (ANC > 1.5 x 10^9/L; platelets > 100 x 10^9/L); hepatic (bilirubin < 1.5 x upper limit of normal [ULN]; AST/ALT < 3 x ULN); renal (calculated creatinine clearance > 60 ml/min).
• Negative pregnancy test for females with child-bearing potential
• Prior radiotherapy allowed but must be delivered to < 25% of bone marrow; must be completed > 4 weeks before study entry; and patients must have recovered from all side effects of the radiotherapy. Radiation must not be delivered to the sole response indicator lesion, unless there is documented evidence of disease progression in that site after completion of radiation.
• Patients must be able to reliably tolerate and comply with oral/feeding tube administered medications (patients are considered eligible if the investigator deems that there is no malabsorption syndrome and no gastrointestinal [GI] obstruction that would impair the delivery of orally administered chemotherapy).
• If patient has had prior anthracycline, cumulative dose must be < 300mg/m2 of doxorubicin or its equivalent.

Exclusion Criteria:

• Abnormal organ function or active infection
• Patients currently enrolled in another clinical trial involving active cancer treatment.
• Treatment with doxorubicin > 300mg/m2 or its equivalent.
• Serious medical conditions including myocardial infarction within 6 months prior to entry; unstable angina; active cardiomyopathy; unstable ventricular arrhythmia; congestive heart failure; uncontrolled hypertension; uncontrolled psychotic disorders; serious active infections; uncontrolled diabetes or any other medical condition that might be aggravated by study treatment.
• Pre-existing neuropathy > grade 1
• History of seizures or patients receiving anti-epileptic prophylaxis
• Active and or progressive brain or leptomeningeal metastasis
• Pregnant or lactating women
• Patients with evidence or recent history of drug or alcohol abuse
• Prior treatment with capecitabine or infusional 5-FU
• Known hypersensitivity to carboplatin
• 5-FU, anthracyclines or known dihydropyrimidine dehydrogenase (DPD) deficiency.
• Patients that lack physical integrity of the gastrointestinal (GI) tract leading to intestinal obstruction.
• Patients taking warfarin (Coumadin) or other coumarin derivatives.
• Presence of any mentally incapacitating psychological condition.