Section on Molecular Transport

Head: Sergey M. Bezrukov

This group studies biomolecular and biophysical mechanisms of membrane transport through \"mesoscopic\" ion channels-channels with relatively large aqueous pores, up to several nanometers in diameter. By analyzing statistical properties of channel-mediated ion currents at the single-channel level, structure/function questions are addressed using original physicochemical approaches such as graded osmotic response, \"molecular Coulter counter\", access resistance, and reversible ionization of the channel amino-acid residues. The Unit has also initiated studies on information transfer in voltage-dependent ion channels with special emphasis on Stochastic Resonance and the role of ambient noise in the biology and medicine of sensory transduction.

Resources

• Employee Listing
• E-Mail the Lab: bezrukos@mail.nih.gov
• SMT Home Page