Cellular and Synaptic Neurophysiology

Head: Christophe J. McBain

This group studies the roles of voltage-gated and neurotransmitter-activated channels in regulating neuronal excitability in the mammalian hippocampus. Electrophysiological, molecular,and immunohistochemical techniques are used to study glutamatergic synaptic transmission. Mechanisms of short and long term plasticity of synaptic transmission are studied in identified hippocampal inhibitory neuron and principal cell populations with regard to both pre- and postsynaptic mechanisms. Research in this group also aims to identify the functional role of voltage-gated potassium channel subunits, expressed in morphologically distinct hippocampal GABA-ergic inhibitory interneurons, during development, oscillatory behavior and pathophysiological processes.

Resources

• Employee Listing
• E-Mail the Lab: chrismcb@codon.nih.gov

Units and Sections

• Section on Cell Biology and Signal Transduction
  Head: James Russell
• Section on Cellular Neurobiology
  Head: Yoke Peng Loh
• Section on Cellular Signaling
  Head: Stanko S. Stojilkovic
• Section on Cellular and Synaptic Physiology
  Head: Christophe J. McBain
• Section on Metabolic Regulation
  Head: Kuo Ping Huang
• Section on Molecular Neurobiology
  Head: Andres Buonanno
• Section on Molecular Signal Transduction
  Head: Tamas Balla
• Section on Neuronal Development
  Head: Bai Lu
• Unit on Molecular Neurophysiology and Biophysics
  Head: Dax A. Hoffman
• Unit on Sensory Coding and Neural Ensembles
  Head: Mark A. Stopfer