Section on Cellular and Developmental Biology

Head: Paul E. Love

Research is directed at understanding the cellular and genetic events that regulate thymocyte development and selection. Current studies are focused primarily on the role of T-cell-receptor-mediated signals in the formation of the mature T cell repertoire. To analyze the function of specific signal transducing proteins, transgenic and gene targeting methods are used to create overexpression, dominant-negative, and loss-of-function mutants in mice. In addition, molecular genetic techniques are being employed to identify and characterize novel genes that are expressed in early thymocytes.

Resources

• Employee Listing
• E-Mail the Lab: pel@helix.nih.gov