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Sponsors and Collaborators: |
University of Aarhus Aarhus University Hospital Vejle Hospital Biomet, Inc. |
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Information provided by: | University of Aarhus |
ClinicalTrials.gov Identifier: | NCT00679120 |
The purpose of this scientific study is to clarify whether there is a relationship between the appearance of radiolucent lines in bone-cement interphase of the tibial component of the different models of the Oxford Uni Knee prosthesis and poor prognosis of these prostheses. This will be accomplished in a se-ries of three different Oxford Uni Knees.
Condition | Intervention |
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Osteoarthritis, Knee |
Device: Oxford Uni Knee |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind (Subject), Parallel Assignment, Safety/Efficacy Study |
Official Title: | Oxford Partial Knee Replacement: A Randomized Clinical Trial of Three Implant Types. |
Estimated Enrollment: | 75 |
Study Start Date: | June 2008 |
Estimated Study Completion Date: | October 2014 |
Estimated Primary Completion Date: | October 2014 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Active Comparator
Cemented single pegged femur with standard tibial bearing tray
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Device: Oxford Uni Knee
Oxford Uni Knee inserted at the time of surgery
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2: Active Comparator
Cemented twin pegged femur with standard tibial bearing tray
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Device: Oxford Uni Knee
Oxford Uni Knee inserted at the time of surgery
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3: Active Comparator
Cementless tibial bearing tray and femur (porous coated and HA coated)
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Device: Oxford Uni Knee
Oxford Uni Knee inserted at the time of surgery (porous coated and HA coated)
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The purpose of this scientific study is to clarify whether there is a relationship between the appearance of radiolucent lines in bone-cement interphase of the tibial component of the different models of the Oxford Uni Knee prosthesis and poor prognosis of these prostheses. This will be accomplished in a se-ries of three different Oxford Uni Knees by studying:
The study would be considered a success if all designs of the prostheses are firmly fixed and remain so during the entire period of study, that is, no increasing migration is seen using RSA. It would be a suc-cess if the appearance of RLL beneath the implant in the proximal tibia is unrelated to bone loss and prosthesis migration.
The hypotheses are:
The primary parameters of effect are RLL, RSA and DEXA. The secondary parameters of effect are bone-remodelling, wear analysis, Oxford Knee Score (ADL) and ROM.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Maiken Stilling, MD | 0045 89497466 | mm-p@dadlnet.dk |
Denmark | |
Orthopaedic Center, Aarhus University Hospital | |
Aarhus, Denmark, 8000 |
Principal Investigator: | Kjeld Soballe, MD, Prof. | Orthopaedic Center, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark |
Responsible Party: | Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C ( Professor Kjeld Soballe ) |
Study ID Numbers: | 20070258 |
Study First Received: | May 14, 2008 |
Last Updated: | May 15, 2008 |
ClinicalTrials.gov Identifier: | NCT00679120 |
Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
Unicompartmental osteoarthrosis RSA Bone-remodelling |
Osteoarthritis, Knee Musculoskeletal Diseases Osteoarthritis Joint Diseases |
Arthritis Rheumatic Diseases Cimetidine |